Post‐myocardial infarction (MI) heart failure is a major public health problem in Western
countries and results from ischemia/reperfusion (IR)‐induced cell death, remodeling, and …

Deficiency in cellular thiol tripeptide glutathione (l-γ glutamyl–cysteinyl–glycine) determines
the severity of several chronic and inflammatory human diseases that may be relieved by …

Amyloid precursor protein (App) plays a crucial role in Alzheimer's disease via the production
and deposition of toxic β-amyloid peptides. App is heavily expressed in neurons, the focus …

Study Objectives: Modafinil is a non-amphetaminic wake-promoting compound used as
therapy against sleepiness and narcolepsy. Its mode of action is complex, but modafinil has …

Using knockout (KO) mice lacking the histamine (HA)-synthesizing enzyme (histidine
decarboxylase, HDC), we have previously shown the importance of histaminergic neurons in …

Oxidative stress contributes to the pathogenesis of Duchenne muscular dystrophy (DMD).
Although they have been a model for DMD, mdx mice exhibit slowly developing …

The objective of this study was to evaluate the levels of plasma bicarbonate levels in
narcoleptic children. Clinical, electrophysiological data and bicarbonate levels were evaluated …

Histamine and orexin (or hypocretin) neurons act distinctly and synergistically in wake control.
A double knockout mouse genotype lacking both histamine and orexins shows all sleep …

Ultrasound (US) neurostimulation, or neuromodulation, is a technique undergoing much
exploration in recent years because of its potential capability of providing a minimally-or …

Objectif La régulation du cycle veille-sommeil dépend de processus cellulaires, moléculaires
et métaboliques dont la connaissance est encore très parcellaire. L’identification de ces …