User profiles for Manuel Alvarez-Dolado

Manuel Alvarez-Dolado

CSIC Tenure Scientist
Verified email at cabimer.es
Cited by 4652

Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes

M Alvarez-Dolado, R Pardal, JM Garcia-Verdugo… - Nature, 2003 - nature.com
Recent studies have suggested that bone marrow cells possess a broad differentiation
potential, being able to form new liver cells, cardiomyocytes and neurons 1 , 2 . Several groups …

[PDF][PDF] Cux1 and Cux2 regulate dendritic branching, spine morphology, and synapses of the upper layer neurons of the cortex

…, E Cisneros, S Kim, A Dopazo, M Alvarez-Dolado… - Neuron, 2010 - cell.com
Dendrite branching and spine formation determines the function of morphologically distinct
and specialized neuronal subclasses. However, little is known about the programs instructing …

Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain

M Alvarez-Dolado, ME Calcagnotto… - Journal of …, 2006 - Soc Neuroscience
Embryonic medial ganglionic eminence (MGE) cells transplanted into the adult brain can
disperse, migrate, and differentiate to neurons expressing GABA, the primary inhibitory …

[PDF][PDF] Nav1. 1-overexpressing interneuron transplants restore brain rhythms and cognition in a mouse model of Alzheimer's disease

…, I Cobos, K Ho, L Gan, L Mucke, M Alvarez-Dolado… - Neuron, 2018 - cell.com
Inhibitory interneurons regulate the oscillatory rhythms and network synchrony that are required
for cognitive functions and disrupted in Alzheimer's disease (AD). Network dysrhythmias …

Thyroid hormone regulates reelin and dab1expression during brain development

M Alvarez-Dolado, M Ruiz, JA Del Rıo… - Journal of …, 1999 - Soc Neuroscience
The reelin and dab1 genes are necessary for appropriate neuronal migration and lamination
during brain development. Since these processes are controlled by thyroid hormone, we …

Dlx-dependent and-independent regulation of olfactory bulb interneuron differentiation

JE Long, S Garel, M Alvarez-Dolado… - Journal of …, 2007 - Soc Neuroscience
Olfactory bulb interneuron development is a complex multistep process that involves cell
specification in the ventral telencephalon, tangential migration into the olfactory bulb, and local …

Specific contribution of Reelin expressed by Cajal–Retzius cells or GABAergic interneurons to cortical lamination

…, M Pascual, M Álvarez-Dolado… - Proceedings of the …, 2022 - National Acad Sciences
The extracellular protein Reelin, expressed by Cajal–Retzius (CR) cells at early stages of
cortical development and at late stages by GABAergic interneurons, regulates radial migration …

Transplant of GABAergic precursors restores hippocampal inhibitory function in a mouse model of seizure susceptibility

…, M Piquer-Gil, LE Mello, M Álvarez-Dolado - Cell …, 2010 - journals.sagepub.com
Defects in GABAergic function can cause epilepsy. In the last years, cell-based therapies
have attempted to correct these defects with disparate success on animal models of epilepsy. …

Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult …

…, M Martínez-Losa, M Álvarez-Dolado… - Disease models & …, 2017 - journals.biologists.com
Cocaine addiction disorder is notably aggravated by concomitant cognitive and emotional
pathology that impedes recovery. We studied whether a persistent cognitive/emotional …

[HTML][HTML] Human mesenchymal stem cells prevent neurological complications of radiotherapy

…, E López, JA Barcia, M Alvarez-Dolado… - Frontiers in cellular …, 2019 - frontiersin.org
Radiotherapy is a highly effective tool for the treatment of brain cancer. However, radiation
also causes detrimental effects in the healthy tissue, leading to neurocognitive sequelae that …