Neuronal growth cones navigate over long distances along specific pathways to find their
correct targets. The mechanisms and molecules that direct this pathfinding are the topics of this …

The visualization of molecularly labeled structures within large intact tissues in three
dimensions is an area of intense focus. We describe a simple, rapid, and inexpensive method, …

In the adult brain, neuroblasts born in the subventricular zone migrate from the walls of the
lateral ventricles to the olfactory bulb. How do these cells orient over such a long distance and …

Extending axons in the developing nervous system are guided in part by repulsive cues.
Genetic analysis in Drosophila, reported in a companion to this paper, identifies the Slit protein …

The guidance of axons to their targets in the developing nervous system is believed to
involve dlffuslble chemotroplc factors secreted by target cells. Floor plate cells at the ventral …

Blood vessels and nerve fibres course throughout the body in an orderly pattern, often
alongside one another. Although superficially distinct, the mechanisms involved in wiring neural …

In vertebrates, commissural axons pioneer a clrcumferentlal pathway to the floor plate at the
ventral midline of the embryonic spinal cord. Floor plate cells secrete a diffusible factor that …

Nerve growth is regulated by attractive and repulsive factors in the nervous system. Microscopic
gradients of Collapsin-1/Semaphorin III/D (Sema III) and myelin-associated glycoprotein …

Axonal and synaptic degeneration is a hallmark of peripheral neuropathy, brain injury, and
neurodegenerative disease. Axonal degeneration has been proposed to be mediated by an …

Midbrain dopaminergic neurons, whose loss in adults results in Parkinson’s disease, can
be specified during embryonic development by a contact-dependent signal from floor plate …