A single-cell genomic atlas for maturation of the human cerebellum during early childhood

SA Ament, M Cortes-Gutierrez, BR Herb… - Science translational …, 2023 - science.org
Inflammation early in life is a clinically established risk factor for autism spectrum disorders
and schizophrenia, yet the impact of inflammation on human brain development is poorly …

Single-nucleus RNA-seq reveals dysregulation of striatal cell identity due to huntington's disease mutations

S Malaiya, M Cortes-Gutierrez, BR Herb… - Journal of …, 2021 - Soc Neuroscience
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by
a trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Cell death in HD occurs …

Impaired Reorganization of Centrosome Structure Underlies Human Infantile Dilated Cardiomyopathy

…, MD Neely, U Sreenivasan, M Cortes-Gutierrez… - Circulation, 2023 - Am Heart Assoc
Background: During cardiomyocyte maturation, the centrosome, which functions as a
microtubule organizing center in cardiomyocytes, undergoes dramatic structural reorganization …

Necrosis of infectious pancreatic necrosis virus (IPNV) infected cells rarely is preceded by apoptosis

JC Espinoza, M Cortés-Gutierrez, J Kuznar - Virus research, 2005 - Elsevier
Infectious pancreatic necrosis virus (IPNV)-infected cells were labeled with Annexin V and
propidium iodide in order to determine the proportion of cells, which developed necrosis and/…

Surface charge potentiates conduction through the cardiac ryanodine receptor channel.

Q Tu, P Velez, M Cortes-Gutierrez, M Fill - The Journal of general …, 1994 - rupress.org
Single channel currents through cardiac sarcoplasmic reticulum (SR) Ca2+ release channels
were measured in very low levels of current carrier (eg, 1 mM Ba2+). The hypothesis that …

Early-childhood inflammation blunts the transcriptional maturation of cerebellar neurons

SA Ament, M Cortes-Gutierrez, BR Herb, E Mocci… - bioRxiv, 2022 - biorxiv.org
Inflammation early in life is a clinically established risk factor for autism spectrum disorders
and schizophrenia, yet the impact of inflammation on human brain development is poorly …

503. Neurodevelopmental Consequences of Rare SETD1A Missense Variants Associated With Risk for Bipolar Disorder

…, RT Oshone, M Cortes-Gutierrez… - Biological …, 2023 - biologicalpsychiatryjournal.com
Background Rare variants with large effects provide excellent opportunities to characterize
causal mechanisms for complex disorders. In recent large-scale exome sequencing studies, …

[PDF][PDF] Characterization of cellular phenotypes through single-nucleus transcriptomic and epigenomic changes during TBI in young and aged mice

P Bhatia, M Cortes-Gutierrez, J Barrett, AI Faden… - 2022 - archive.hshsl.umaryland.edu
Background: • Damage caused in the primary phase of TBI leads to chronic neurodegenerative
processes leading to increased risk of psychiatric disorders like Alzheimer’s disease (AD)…

[PDF][PDF] Luminal Regulation of Single RyR2 Channels by Cardiac Calsequestrin

M Cortes-Gutierrez, HR Orrell, S Williams, P Velez… - Biophysical …, 2010 - cell.com
We examined the hypothesis that calsequestrin (CSQ2) can regulate the RyR2 activity
using a combination of single channel electrophysiology and lanthanide resonance energy …

[CITATION][C] SINGLE-CELL GENOMICS REVEALS EFFECTS OF CHILDHOOD INFLAMMATION DURING THE POSTNATAL MATURATION OF THE HUMAN …

S Ament, S Arambula, M Cortes-Gutierrez… - European …, 2022 - Elsevier