A single-cell genomic atlas for maturation of the human cerebellum during early childhood
Inflammation early in life is a clinically established risk factor for autism spectrum disorders
and schizophrenia, yet the impact of inflammation on human brain development is poorly …
and schizophrenia, yet the impact of inflammation on human brain development is poorly …
Single-nucleus RNA-seq reveals dysregulation of striatal cell identity due to huntington's disease mutations
S Malaiya, M Cortes-Gutierrez, BR Herb… - Journal of …, 2021 - Soc Neuroscience
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by
a trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Cell death in HD occurs …
a trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Cell death in HD occurs …
Impaired Reorganization of Centrosome Structure Underlies Human Infantile Dilated Cardiomyopathy
…, MD Neely, U Sreenivasan, M Cortes-Gutierrez… - Circulation, 2023 - Am Heart Assoc
Background: During cardiomyocyte maturation, the centrosome, which functions as a
microtubule organizing center in cardiomyocytes, undergoes dramatic structural reorganization …
microtubule organizing center in cardiomyocytes, undergoes dramatic structural reorganization …
Necrosis of infectious pancreatic necrosis virus (IPNV) infected cells rarely is preceded by apoptosis
JC Espinoza, M Cortés-Gutierrez, J Kuznar - Virus research, 2005 - Elsevier
Infectious pancreatic necrosis virus (IPNV)-infected cells were labeled with Annexin V and
propidium iodide in order to determine the proportion of cells, which developed necrosis and/…
propidium iodide in order to determine the proportion of cells, which developed necrosis and/…
Surface charge potentiates conduction through the cardiac ryanodine receptor channel.
Q Tu, P Velez, M Cortes-Gutierrez, M Fill - The Journal of general …, 1994 - rupress.org
Single channel currents through cardiac sarcoplasmic reticulum (SR) Ca2+ release channels
were measured in very low levels of current carrier (eg, 1 mM Ba2+). The hypothesis that …
were measured in very low levels of current carrier (eg, 1 mM Ba2+). The hypothesis that …
Early-childhood inflammation blunts the transcriptional maturation of cerebellar neurons
Inflammation early in life is a clinically established risk factor for autism spectrum disorders
and schizophrenia, yet the impact of inflammation on human brain development is poorly …
and schizophrenia, yet the impact of inflammation on human brain development is poorly …
503. Neurodevelopmental Consequences of Rare SETD1A Missense Variants Associated With Risk for Bipolar Disorder
…, RT Oshone, M Cortes-Gutierrez… - Biological …, 2023 - biologicalpsychiatryjournal.com
Background Rare variants with large effects provide excellent opportunities to characterize
causal mechanisms for complex disorders. In recent large-scale exome sequencing studies, …
causal mechanisms for complex disorders. In recent large-scale exome sequencing studies, …
[PDF][PDF] Characterization of cellular phenotypes through single-nucleus transcriptomic and epigenomic changes during TBI in young and aged mice
Background: • Damage caused in the primary phase of TBI leads to chronic neurodegenerative
processes leading to increased risk of psychiatric disorders like Alzheimer’s disease (AD)…
processes leading to increased risk of psychiatric disorders like Alzheimer’s disease (AD)…
[PDF][PDF] Luminal Regulation of Single RyR2 Channels by Cardiac Calsequestrin
M Cortes-Gutierrez, HR Orrell, S Williams, P Velez… - Biophysical …, 2010 - cell.com
We examined the hypothesis that calsequestrin (CSQ2) can regulate the RyR2 activity
using a combination of single channel electrophysiology and lanthanide resonance energy …
using a combination of single channel electrophysiology and lanthanide resonance energy …
[CITATION][C] SINGLE-CELL GENOMICS REVEALS EFFECTS OF CHILDHOOD INFLAMMATION DURING THE POSTNATAL MATURATION OF THE HUMAN …
S Ament, S Arambula, M Cortes-Gutierrez… - European …, 2022 - Elsevier