User profiles for Maria A. Gandini
Maria A Gandiniresearch associate Verified email at ucalgary.ca Cited by 902 |
[PDF][PDF] De novo pathogenic variants in CACNA1E cause developmental and epileptic encephalopathy with contractures, macrocephaly, and dyskinesias
…, CT Myers, B Uysal, N Schwarz, MA Gandini… - The American Journal of …, 2018 - cell.com
Developmental and epileptic encephalopathies (DEEs) are severe neurodevelopmental
disorders often beginning in infancy or early childhood that are characterized by intractable …
disorders often beginning in infancy or early childhood that are characterized by intractable …
Differential regulation of Cav3.2 and Cav2.2 calcium channels by CB1 receptors and cannabidiol
Background and Purpose Cannabinoids are a promising therapeutic avenue for chronic pain.
However, clinical trials often fail to report analgesic efficacy of cannabinoids. Inhibition of …
However, clinical trials often fail to report analgesic efficacy of cannabinoids. Inhibition of …
Regulation of L-type CaV1. 3 channel activity and insulin secretion by the cGMP-PKG signaling pathway
cGMP is a second messenger widely used in the nervous system and other tissues. One of
the major effectors for cGMP is the serine/threonine protein kinase, cGMP-dependent protein …
the major effectors for cGMP is the serine/threonine protein kinase, cGMP-dependent protein …
CaV3. 2 calcium channels contribute to trigeminal neuralgia
Trigeminal neuralgia (TN) is a rare but debilitating disorder characterized by excruciating
facial pain, with a higher incidence in women. Recent studies demonstrated that TN patients …
facial pain, with a higher incidence in women. Recent studies demonstrated that TN patients …
Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons
…, ER Mustafa, VM Damonte, MA Gandini… - Journal of General …, 2015 - rupress.org
The growth hormone secretagogue receptor type 1a (GHSR1a) has the highest known
constitutive activity of any G protein–coupled receptor (GPCR). GHSR1a mediates the action of …
constitutive activity of any G protein–coupled receptor (GPCR). GHSR1a mediates the action of …
[HTML][HTML] Familial hemiplegic migraine type 1 mutations W1684R and V1696I alter G protein-mediated regulation of CaV2. 1 voltage-gated calcium channels
…, A Sandoval, R González-Ramírez, MA Gandini… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Familial hemiplegic migraine type 1 (FHM-1) is a monogenic form of migraine with aura that
is characterized by recurrent attacks of a typical migraine headache with transient …
is characterized by recurrent attacks of a typical migraine headache with transient …
CaV2.2 channel cell surface expression is regulated by the light chain 1 (LC1) of the microtubule-associated protein B (MAP1B) via UBE2L3-mediated ubiquitination …
MA Gandini, DR Henríquez, L Grimaldo… - … -European Journal of …, 2014 - Springer
Microtubule-associated protein B is a cytoskeleton protein consisting of heavy and light (LC)
chains that play important roles in the regulation of neuronal morphogenesis and function. …
chains that play important roles in the regulation of neuronal morphogenesis and function. …
Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury–associated peripheral sensory neuropathy via block of N …
The Federal Pain Research Strategy recommended development of nonopioid analgesics
as a top priority in its strategic plan to address the significant public health crisis and …
as a top priority in its strategic plan to address the significant public health crisis and …
RIM1/2-mediated facilitation of Cav1. 4 channel opening is required for Ca2+-stimulated release in mouse rod photoreceptors
CP Grabner, MA Gandini, R Rehak, Y Le… - Journal of …, 2015 - Soc Neuroscience
Night blindness can result from impaired photoreceptor function and a subset of cases have
been linked to dysfunction of Cav1.4 calcium channels and in turn compromised synaptic …
been linked to dysfunction of Cav1.4 calcium channels and in turn compromised synaptic …
[PDF][PDF] Hyperactivity of innate immunity triggers pain via TLR2-IL-33-mediated neuroimmune crosstalk
J Huang, MA Gandini, L Chen, S M'Dahoma… - Cell Reports, 2020 - cell.com
The innate immune system responds to infections that give rise to pain. How the innate
immune system interacts with the sensory nervous system and contributes to pain is poorly …
immune system interacts with the sensory nervous system and contributes to pain is poorly …