User profiles for Maria C. Marchetto
Maria Carolina MarchettoUniversity of California, San Diego and Salk Institute for Biological Studies Verified email at salk.edu Cited by 19223 |
Induced pluripotent stem cells: the new patient?
Worldwide increases in life expectancy have been paralleled by a greater prevalence of
chronic and age-associated disorders, particularly of the cardiovascular, neural and metabolic …
chronic and age-associated disorders, particularly of the cardiovascular, neural and metabolic …
Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder
…, T Eames, ST Schafer, L Boyer, MC Marchetto… - Nature, 2015 - nature.com
Bipolar disorder is a complex neuropsychiatric disorder that is characterized by intermittent
episodes of mania and depression; without treatment, 15% of patients commit suicide 1 . …
episodes of mania and depression; without treatment, 15% of patients commit suicide 1 . …
Altered proliferation and networks in neural cells derived from idiopathic autistic individuals
Autism spectrum disorders (ASD) are common, complex and heterogeneous neurodevelopmental
disorders. Cellular and molecular mechanisms responsible for ASD pathogenesis …
disorders. Cellular and molecular mechanisms responsible for ASD pathogenesis …
Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience
The scarcity of live human brain cells for experimental access has for a long time limited our
ability to study complex human neurological disorders and elucidate basic neuroscientific …
ability to study complex human neurological disorders and elucidate basic neuroscientific …
[PDF][PDF] 2D and 3D stem cell models of primate cortical development identify species-specific differences in progenitor behavior contributing to brain size
Variation in cerebral cortex size and complexity is thought to contribute to differences in
cognitive ability between humans and other animals. Here we compare cortical progenitor cell …
cognitive ability between humans and other animals. Here we compare cortical progenitor cell …
Mobile DNA elements in the generation of diversity and complexity in the brain
Mobile elements are DNA sequences that can change their position (retrotranspose) within
the genome. Although its biological function is largely unappreciated, DNA derived from …
the genome. Although its biological function is largely unappreciated, DNA derived from …
Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons
Autism spectrum disorder (ASD) is thought to emerge during early cortical development.
However, the exact developmental stages and associated molecular networks that prime …
However, the exact developmental stages and associated molecular networks that prime …
Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises
MC Marchetto, KJ Brennand, LF Boyer… - Human molecular …, 2011 - academic.oup.com
The systematic generation of neurons from patients with neurological disorders can provide
important insights into disease pathology, progression and mechanism. This review will …
important insights into disease pathology, progression and mechanism. This review will …
[HTML][HTML] A quantitative framework to evaluate modeling of cortical development by neural stem cells
Neural stem cells have been adopted to model a wide range of neuropsychiatric conditions
in vitro. However, how well such models correspond to in vivo brain has not been evaluated …
in vitro. However, how well such models correspond to in vivo brain has not been evaluated …
A human neurodevelopmental model for Williams syndrome
Williams syndrome is a genetic neurodevelopmental disorder characterized by an uncommon
hypersociability and a mosaic of retained and compromised linguistic and cognitive …
hypersociability and a mosaic of retained and compromised linguistic and cognitive …