DMSO is one of the most common solvents used experimentally to dissolve hydrophobic
substances for in vivo and in vitro purposes. A wide range of pharmacological effects exerted by …

Bv8, prokineticin-1 or EG-VEGF (endocrine gland-derived vascular endothelial growth factor),
and prokineticin-2, are naturally occurring peptide agonists of two G-protein-coupled …

Small mammalian proteins called the prokineticins [prokineticin 1 (PK1) and PK2] and two
corresponding G-protein-coupled receptors [prokineticin receptor 1 (PKR1) and PKR2] have …

The small protein Bv8, isolated from amphibian skin, belongs to a novel family of secretory
proteins (Bv8‐Prokineticin family, SWISS‐PROT: Q9PW66) whose orthologues have been …

A number of pyridazinone derivatives bearing an arylpiperazinylalkyl chain were synthesized
and tested icv in a model of acute nociception induced by thermal stimuli in mice (tail flick). …

A new environment-sensitive fluorophore, 6-N,N-(dimethylamino)-2,3-naphthalimide (6DMN)
was introduced in the δ-selective opioid peptide agonist H-Dmt-Tic-Glu-NH 2 and in the μ-…

Formyl peptide receptor type 2 (FPR2/ALX) belongs to the formyl peptide receptors (FPRs)
family clustered on chromosome 19 and encodes a family of three Class A of G protein-…

The small protein Bv8, secreted by the skin of the frog Bombina variegata, belongs to a novel
family of secreted proteins whose orthologues have been identified in snakes (MIT) and in …

The potential anxiolytic and anti-depressive activity of CMP1 was studied in the elevated
plus-maze test and in the forced swimming test. Furthermore, CMP1 sedative activity was …

Pyridazine derivatives, such as arylpiperazinylalkyl pyridazinones, display antinociceptive
effects to thermal and chemical stimuli. Here, we extended our previous knowledge on the …