Covalent attachment of myristate and/or palmitate occurs on a wide variety of viral and
cellular proteins. This review will highlight the latest advances in our understanding of the …

Three-dimensional structures of complexes of the SH2 domain of the v-src oncogene
product with two phosphotyrosyl peptides have been determined by X-ray crystallography at …

Retroviral Gag proteins are targeted to the plasma membrane, where they play the central
role in virion formation. Several studies have suggested that the membrane-binding signal is …

A wide variety of signaling proteins are modified by covalently linked fatty acids and/or
prenyl groups. These hydrophobic moieties, which include myristate, palmitate, farnesyl and …

The ability of the Src family kinases Fyn and Lck to participate in signaling through the T cell
receptor is critically dependent on their dual fatty acylation with myristate and palmitate. …

Palmitate, a 16-carbon saturated fatty acid, is attached to more than 100 proteins. Modification
of proteins by palmitate has pleiotropic effects on protein function. Palmitoylation can …

Budding of lentiviruses occurs at the plasma membrane, but the preceding steps involved in
particle assembly are poorly understood. Since the Gag polyprotein mediates virion …

Palmitoylation of Sonic Hedgehog (Shh) is critical for effective long- and short-range signaling.
Genetic screens uncovered a potential palmitoylacyltransferase (PAT) for Shh, Hhat, but …

Differentiation of oligodendrocyte progenitor cells requires activation of the Src family kinase
Fyn. The signals that are upstream and downstream of Fyn in oligodendrocytes remain …

Membrane targeting of pp60src (Src) is mediated by its myristoylated amino terminus. We
demonstrate that, in addition to myristate, six basic residues in the amino terminus are …