ERK1/2 activation in preexisting oligodendrocytes of adult mice drives new myelin synthesis and enhanced CNS function
MA Jeffries, K Urbanek, L Torres… - Journal of …, 2016 - Soc Neuroscience
Growing evidence shows that mechanisms controlling CNS plasticity extend beyond the
synapse and that alterations in myelin can modify conduction velocity, leading to changes in …
synapse and that alterations in myelin can modify conduction velocity, leading to changes in …
[HTML][HTML] Peripheral immune dysfunction: a problem of central importance after spinal cord injury
MA Jeffries, VJ Tom - Biology, 2021 - mdpi.com
Simple Summary Spinal cord injury can result in an increased vulnerability to infections, but
until recently the biological mechanisms behind this observation were not well defined. …
until recently the biological mechanisms behind this observation were not well defined. …
mTOR signaling regulates metabolic function in oligodendrocyte precursor cells and promotes efficient brain remyelination in the cuprizone model
MA Jeffries, LE McLane, L Khandker… - Journal of …, 2021 - Soc Neuroscience
In demyelinating diseases, such as multiple sclerosis, primary loss of myelin and subsequent
neuronal degeneration throughout the CNS impair patient functionality. While the …
neuronal degeneration throughout the CNS impair patient functionality. While the …
[PDF][PDF] Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord
L Khandker, MA Jeffries, YJ Chang, ML Mather… - Cell reports, 2022 - cell.com
Brain and spinal cord oligodendroglia have distinct functional characteristics, and cell-autonomous
loss of individual genes can result in different regional phenotypes. However, a …
loss of individual genes can result in different regional phenotypes. However, a …
Mechanistic target of rapamycin regulates the oligodendrocyte cytoskeleton during myelination
AS Musah, TL Brown, MA Jeffries, Q Shang… - Journal of …, 2020 - Soc Neuroscience
During differentiation, oligodendrocyte precursor cells (OPCs) extend a network of processes
that make contact with axons and initiate myelination. Recent studies revealed that actin …
that make contact with axons and initiate myelination. Recent studies revealed that actin …
Cnp Promoter-Driven Sustained ERK1/2 Activation Increases B-Cell Activation and Suppresses Experimental Autoimmune Encephalomyelitis
MA Jeffries, AE Obr, K Urbanek… - ASN …, 2020 - journals.sagepub.com
The ERK1/2 signaling pathway promotes myelin wrapping during development and
remyelination, and sustained ERK1/2 activation in the oligodendrocyte (OL) lineage results in …
remyelination, and sustained ERK1/2 activation in the oligodendrocyte (OL) lineage results in …
The mechanistic target of rapamycin as a regulator of metabolic function in oligodendroglia during remyelination
ML Mather, MA Jeffries, TL Wood - Current opinion in pharmacology, 2022 - Elsevier
Despite evidence for prominent metabolic dysfunction within multiple sclerosis (MS) lesions,
the mechanisms controlling metabolic shifts in oligodendroglia are poorly understood. The …
the mechanisms controlling metabolic shifts in oligodendroglia are poorly understood. The …
Single-cell Sequencing Reveals Brain/Spinal Cord Oligodendrocyte Precursor Heterogeneity and Requirement for mTOR in Cholesterol Biosynthesis and Myelin …
L Khandker, MA Jeffries, YJ Chang, ML Mather… - bioRxiv, 2020 - biorxiv.org
Brain and spinal cord oligodendroglia have distinct functional characteristics, and cell
autonomous loss of individual genes can result in different regional phenotypes. However, …
autonomous loss of individual genes can result in different regional phenotypes. However, …
Pediatric organ dysfunction information update mandate (PODIUM) contemporary organ dysfunction criteria: executive summary
…, M Hartman, AB Hassinger, SY Irving, H Jeffries… - …, 2022 - publications.aap.org
Prior criteria for organ dysfunction in critically ill children were based mainly on expert
opinion. We convened the Pediatric Organ Dysfunction Information Update Mandate (PODIUM) …
opinion. We convened the Pediatric Organ Dysfunction Information Update Mandate (PODIUM) …
Laser-Induced Thermal Decomposition of Uranium Coordination Compounds with Non-oxidic Ligands to Produce Nitride and Carbide Materials
…, LD Winston, JN Burks, AA Martin, JR Jeffries… - Inorganic …, 2024 - ACS Publications
The production of ceramics from uranium coordination compounds can be achieved through
thermal processing if an excess amount of the desired atoms (ie, C or N), or reactive …
thermal processing if an excess amount of the desired atoms (ie, C or N), or reactive …