Research in the past decades has unfolded the multifaceted role of Fragile X mental
retardation protein (FMRP) and how its absence contributes to the pathophysiology of Fragile X …

Fragile X syndrome (FXS) is caused by the loss of the fragile X mental retardation protein (FMRP),
an RNA binding protein that regulates translation of numerous target mRNAs, some of …

Repeat-associated non-AUG-initiated translation of expanded CGG repeats (CGG RAN)
from the FMR1 5′-leader produces toxic proteins that contribute to neurodegeneration in …

Virus-Induced Chaperone-Enriched (VICE) domains form adjacent to nuclear viral replication
compartments (RC) during the early stages of HSV-1 infection. Between 2 and 3 hours …

Dendritic RNAs are localized and translated in RNA granules. Here we use single-molecule
imaging to count the number of RNA molecules in each granule and to record translation …

The ubiquitination/proteasome system is important for the spatiotemporal control of protein
synthesis and degradation at synapses, while dysregulation may underlie autism spectrum …

Fragile X syndrome is a common cause of intellectual disability and autism spectrum disorder.
The gene underlying the disorder, fragile X mental retardation 1 (FMR1), is silenced in …

Fragile X Messenger Ribonucleoprotein (FMRP) is necessary for experience-dependent,
developmental synapse elimination and the loss of this process may underlie the excess …

Neurons and endocrine cells package peptides in secretory granules (large dense-core
vesicles) for storage and stimulated release. Studies of peptidylglycine α-amidating …

In neurons, specific RNAs are assembled into granules, which are translated in dendrites,
however the functional consequences of granule assembly are not known. Tumor …