Transient blockade of the CD11d/CD18 integrin reduces secondary damage after spinal cord injury, improving sensory, autonomic, and motor function
D Gris, DR Marsh, MA Oatway, Y Chen… - Journal of …, 2004 - Soc Neuroscience
The early inflammatory response to spinal cord injury (SCI) causes significant secondary
damage. Strategies that nonselectively suppress inflammation have not improved outcomes …
damage. Strategies that nonselectively suppress inflammation have not improved outcomes …
Chronic pain after clip-compression injury of the rat spinal cord
JC Bruce, MA Oatway, LC Weaver - Experimental neurology, 2002 - Elsevier
Chronic tactile allodynia and hyperalgesia are frequent complications of spinal cord injury (SCI)
with poorly understood mechanisms. Possible causes are plastic changes in the central …
with poorly understood mechanisms. Possible causes are plastic changes in the central …
The 5-HT3 receptor facilitates at-level mechanical allodynia following spinal cord injury
MA Oatway, Y Chen, LC Weaver - Pain, 2004 - journals.lww.com
Spinal cord injury (SCI) results in the development of mechanical allodynia immediately
rostral to the lesion site, within the dermatome border of normal sensation and sensory loss (at-…
rostral to the lesion site, within the dermatome border of normal sensation and sensory loss (at-…
Anti-CD11d integrin antibody treatment restores normal serotonergic projections to the dorsal, intermediate, and ventral horns of the injured spinal cord
MA Oatway, Y Chen, JC Bruce… - Journal of …, 2005 - Soc Neuroscience
Spinal serotonergic pathways provide inhibitory and excitatory modulation of sensory,
autonomic, and motor processing. After spinal cord injury (SCI), the acute inflammatory response …
autonomic, and motor processing. After spinal cord injury (SCI), the acute inflammatory response …
Blockade of the 5‐HT3 receptor for days causes sustained relief from mechanical allodynia following spinal cord injury
Y Chen, MA Oatway, LC Weaver - Journal of neuroscience …, 2009 - Wiley Online Library
Chronic neuropathic pain is a frequent, serious outcome of spinal cord injury (SCI) that is
highly refractory to treatment. Serotonin can contribute to neuropathic pain after SCI, as …
highly refractory to treatment. Serotonin can contribute to neuropathic pain after SCI, as …
Methylprednisolone causes minimal improvement after spinal cord injury in rats, contrasting with benefits of an anti-integrin treatment
Spinal cord injury (SCI) leads to complex secondary events that expand and exacerbate the
injury. Methylprednisolone (MP) has been considered a standard of care for acute SCI. The …
injury. Methylprednisolone (MP) has been considered a standard of care for acute SCI. The …
Peripheral antihyperalgesic and analgesic actions of ketamine and amitriptyline in a model of mild thermal injury in the rat
M Oatway, A Reid, J Sawynok - Anesthesia & Analgesia, 2003 - journals.lww.com
IMPLICATIONS: This study examines the pain-relieving properties of the local peripheral
administration of ketamine and amitriptyline, two drugs in current clinical use, in a thermal injury …
administration of ketamine and amitriptyline, two drugs in current clinical use, in a thermal injury …
[HTML][HTML] Exploring the distribution of prescription for sulfonylureas in patients with type 2 diabetes according to cardiovascular risk factors within a Canadian primary …
P Farahani, S Khan, M Oatway, A Dziarmaga - Journal of Population …, 2015 - jptcp.com
Background A growing body of evidence generated from observational studies and meta-analyses
has begun to illustrate the potential adverse cardiovascular (CV) risk profile …
has begun to illustrate the potential adverse cardiovascular (CV) risk profile …
Gene expression profiling in anti-CD11d mAb-treated spinal cord-injured rats
…, A Tighe, S Thawer, A Hemphill, M Oatway… - Journal of …, 2009 - Elsevier
Acute administration of a mononclonal antibody (mAb) raised against the CD11d subunit of
the leukocyte CD11d/CD18 integrin after spinal cord injury (SCI) in the rat greatly improves …
the leukocyte CD11d/CD18 integrin after spinal cord injury (SCI) in the rat greatly improves …
[CITATION][C] Guntinas-Lichius, Orlando, 207 Guo, Zhihong, 294
…, G Nappi, S Narr, WF Neiss, HK Ng, MA Oatway - Experimental Neurology, 2002