We determined that two mouse cryptochrome genes, mCry1 and mCry2, act in the negative
limb of the clock feedback loop. In cell lines, mPER proteins (alone or in combination) have …

We examined the transcriptional regulation of the clock-controlled arginine vasopressin gene
in the suprachiasmatic nuclei (SCN). A core clock mechanism in mouse SCN appears to …

We have cloned and characterized the mouse cDNA of a third mammalian homolog of the
Drosophila period gene and designated it mPer3. The mPER3 protein shows ∼37% amino …

We have characterized a mammalian homolog of the Drosophila period gene and designated
it Per2. The PER2 protein shows >40% amino acid identity to the protein of another …

The brain receives sensory input from diverse peripheral tissues, including the skin, the
body's largest sensory organ. Using genetically encoded axonal tracers expressed from the …

In vertebrates, peripheral chemosensory neurons express large families of G protein-coupled
receptors (GPCRs), reflecting the diversity and specificity of stimuli they detect. However, …

Behavioral responses to painful stimuli require peripheral sensory neurons called
nociceptors. Electrophysiological studies show that most C-fiber nociceptors are polymodal (ie, …

Topoisomerases are expressed throughout the developing and adult brain and are mutated
in some individuals with autism spectrum disorder (ASD). However, how topoisomerases …

With the increased use of small self-complementary adeno-associated viral (AAV) vectors,
the design of compact promoters becomes critical for packaging and expressing larger …

Angelman syndrome is a severe neurodevelopmental disorder caused by deletion or mutation
of the maternal allele of the ubiquitin protein ligase E3A (UBE3A) 1 , 2 , 3 . In neurons, the …