The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large
number of genetic studies and by many human diseases that involve the disruption of lipid …

A group of phosphoinositide 3-kinase (PI3K) inhibitors, such as 3-methyladenine (3-MA) and
wortmannin, have been widely used as autophagy inhibitors based on their inhibitory effect …

Growing evidence suggests that phosphoinositides play an important role in membrane
traffic. A polyphosphoinositide phosphatase, synaptojanin 1, was identified as a major …

Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is essential for normal brain
growth and cognitive function 1 , 2 , 3 , 4 . Consistent with its importance in the brain, DHA is …

Obesity is associated with an enhanced inflammatory response that exacerbates insulin
resistance and contributes to diabetes, atherosclerosis, and cardiovascular disease. One …

Once viewed simply as a reservoir for carbon storage, lipids are no longer cast as bystanders
in the drama of biological systems. The emerging field of lipidomics is driven by technology…

Lipids are key regulators of brain function and have been increasingly implicated in
neurodegenerative disorders including Alzheimer disease (AD). Here, a systems-based approach …

Lipid transfer between cell membrane bilayers at contacts between the endoplasmic reticulum
(ER) and other membranes help to maintain membrane lipid homeostasis. We found that …

Membrane phosphoinositides control a variety of cellular processes through the recruitment
and/or regulation of cytosolic proteins 1 , 2 , 3 , 4 . One mechanism ensuring spatial …

Lipid droplets (LDs) are emerging cellular organelles that are of crucial importance in cell
biology and human diseases. In this study, we present our screen of ∼4,700 Saccharomyces …