Seeing the forest tree by tree: super-resolution light microscopy meets the neurosciences
M Maglione, SJ Sigrist - Nature neuroscience, 2013 - nature.com
Light microscopy can be applied in vivo and can sample large tissue volumes, features
crucial for the study of single neurons and neural circuits. However, light microscopy per se is …
crucial for the study of single neurons and neural circuits. However, light microscopy per se is …
Ultrafast, temporally stochastic STED nanoscopy of millisecond dynamics
J Schneider, J Zahn, M Maglione, SJ Sigrist… - Nature …, 2015 - nature.com
Electro-optical scanning (>1,000 frames/s) with pixel dwell times on the order of the lifetime
of the fluorescent molecular state renders stimulated emission depletion (STED) nanoscopy …
of the fluorescent molecular state renders stimulated emission depletion (STED) nanoscopy …
RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses
MK Grauel, M Maglione, S Reddy-Alla… - Proceedings of the …, 2016 - National Acad Sciences
The tight spatial coupling of synaptic vesicles and voltage-gated Ca 2+ channels (Ca V s)
ensures efficient action potential-triggered neurotransmitter release from presynaptic active …
ensures efficient action potential-triggered neurotransmitter release from presynaptic active …
[HTML][HTML] Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses
M Maglione, G Kochlamazashvili, T Eisenberg… - Scientific Reports, 2019 - nature.com
Aging is associated with functional alterations of synapses thought to contribute to age-dependent
memory impairment (AMI). While therapeutic avenues to protect from AMI are largely …
memory impairment (AMI). While therapeutic avenues to protect from AMI are largely …
Panglial gap junctional communication is essential for maintenance of myelin in the CNS
O Tress, M Maglione, D May, T Pivneva… - Journal of …, 2012 - Soc Neuroscience
In this study, we have investigated the contribution of oligodendrocytic connexin47 (Cx47)
and astrocytic Cx30 to panglial gap junctional networks as well as myelin maintenance and …
and astrocytic Cx30 to panglial gap junctional networks as well as myelin maintenance and …
[PDF][PDF] Stable positioning of Unc13 restricts synaptic vesicle fusion to defined release sites to promote synchronous neurotransmission
…, C Beis, AT Grasskamp, MM Mampell, M Maglione… - Neuron, 2017 - cell.com
Neural information processing depends on precisely timed, Ca 2+ -activated synaptic vesicle
exocytosis from release sites within active zones (AZs), but molecular details are unknown. …
exocytosis from release sites within active zones (AZs), but molecular details are unknown. …
Interactive nanocluster compaction of the ELKS scaffold and Cacophony Ca2+ channels drives sustained active zone potentiation
…, K Esch, J Lützkendorf, H Depner, M Maglione… - Science …, 2023 - science.org
At presynaptic active zones (AZs), conserved scaffold protein architectures control synaptic
vesicle (SV) release by defining the nanoscale distribution and density of voltage-gated Ca 2…
vesicle (SV) release by defining the nanoscale distribution and density of voltage-gated Ca 2…
[HTML][HTML] Unc13A and Unc13B contribute to the decoding of distinct sensory information in Drosophila
A Pooryasin, M Maglione, M Schubert… - Nature …, 2021 - nature.com
The physical distance between presynaptic Ca 2+ channels and the Ca 2+ sensors
triggering the release of neurotransmitter-containing vesicles regulates short-term plasticity (STP). …
triggering the release of neurotransmitter-containing vesicles regulates short-term plasticity (STP). …
Oligodendrocytes in mouse corpus callosum are coupled via gap junction channels formed by connexin47 and connexin32
According to previously published ultrastructural studies, oligodendrocytes in white matter
exhibit gap junctions with astrocytes, but not among each other, while in vitro …
exhibit gap junctions with astrocytes, but not among each other, while in vitro …
[HTML][HTML] Spermidine suppresses age-associated memory impairment by preventing adverse increase of presynaptic active zone size and release
Memories are assumed to be formed by sets of synapses changing their structural or functional
performance. The efficacy of forming new memories declines with advancing age, but the …
performance. The efficacy of forming new memories declines with advancing age, but the …