A gene, ATM, that is mutated in the autosomal recessive disorder ataxia telangiectasia (AT)
was identified by positional cloning on chromosome 11q22-23. AT is characterized by …

The ataxia-telangiectasia mutated (ATM) protein kinase is activated by DNA double-strand
breaks (DSBs) through the Mre11-Rad50-Nbs1 (MRN) DNA repair complex and orchestrates …

First described over 80 years ago, ataxia-telangiectasia (AT) was defined as a clinical entity
50 years ago. Although not encountered by most clinicians, it is a paradigm for cancer …

▪ Abstract The autosomal recessive human disorder ataxia-telangiectasia (AT) was first
described as a separate disease entity 40 years ago. It is a multisystem disease characterized by …

Background The absence of trial data comparing robot-assisted laparoscopic prostatectomy
and open radical retropubic prostatectomy is a crucial knowledge gap in uro-oncology. We …

The human genetic disorder ataxia-telangiectasia (AT) is characterized by immunodeficiency,
progressive cerebellar ataxia, radiosensitivity, cell cycle checkpoint defects and cancer …

Mutations in the gene ATM are responsible for the genetic disorder ataxia-telangiectasia (AT),
which is characterized by cerebellar dysfunction, radiosensitivity, chromosomal instability …

Well before the gene (ATM) mutated in the human genetic disorder ataxia-telangiectasia (AT)
was described it was evident from the clinical, molecular and cellular phenotype of AT that …

Background Previous trials have found similar early outcomes after robot-assisted laparoscopic
prostatectomy and open radical retropubic prostatectomy. We report functional and …

ATM kinase plays a central role in signaling DNA double‐strand breaks to cell cycle
checkpoints and to the DNA repair machinery. Although the exact mechanism of ATM activation …