Myasthenia gravis (MG) is a severely debilitating autoimmune disease that is due to a decrease
in the efficiency of synaptic transmission at neuromuscular synapses. MG is caused by …

Extracellular protein profiles from wild-type and regulatory or secretory isogenic mutants of
the Pseudomonas aeruginosa exoenzyme S regulon were compared to identify proteins …

At the neuromuscular junction, the acetylcholine receptor (AChR) is specifically clustered in
the postsynaptic membrane via interactions with rapsyn and other scaffolding proteins. …

Shc family proteins serve as phosphotyrosine adaptor molecules in various receptor-mediated
signaling pathways. In mammals, three distinct Shc genes have been described that …

Agrin activates MuSK, a receptor tyrosine kinase expressed in skeletal muscle, leading to
tyrosine phosphorylation of the acetylcholine receptor(AChR) β-subunit and clustering of …

Synthetic oxytocin (sOT) is widely used during labor, yet little is known about its effects on
fetal brain development despite evidence that it reaches the fetal circulation. Here, we tested …

Neurocognitive dysfunction is common in survivors of intensive care. Prolonged sedation has
been implicated but the mechanisms are unclear. Neurogenesis continues into adulthood …

The development and maintenance of neural circuits is highly sensitive to neural activity.
General anesthetics have profound effects on neural activity and, as such, there is concern that …

Key genes, such as Agrin, Lrp4, and MuSK, are required for the initial formation, subsequent
maturation, and long-term stabilization of mammalian neuromuscular synapses. Additional …

Surgery is a major challenge for the immune system, but little is known about the immune
response of geriatric patients to surgery. We therefore investigated the impact of surgery on the …