Mutations in the amyloid precursor protein (APP) gene cause early-onset familial Alzheimer
disease (AD) by affecting the formation of the amyloid β (Aβ) peptide, the major constituent …

We have generated a novel transgenic mouse model on a C57BL/6J genetic background
that coexpresses KM670/671NL mutated amyloid precursor protein and L166P mutated …

Context Autism often involves early brain overgrowth, including the prefrontal cortex (PFC).
Although prefrontal abnormality has been theorized to underlie some autistic symptoms, the …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects a large
proportion of the elderly population. Amyloid plaques, which are a neuro-pathological …

Microglial cells aggregate around amyloid plaques in Alzheimer's disease, but, despite their
therapeutic potential, various aspects of their reactive kinetics and role in plaque …

Transgenic mice that overexpress mutant human amyloid precursor protein (APP) exhibit one
hallmark of Alzheimer’s disease pathology, namely the extracellular deposition of amyloid …

Development, ageing, and a variety of neurological disorders are characterized by selective
alterations in specific populations of nerve cells which are, in turn, associated with changes …

The morphological changes that occur during normal brain aging are not well understood.
This study used modern stereology to assess the effects of age and gender on total numbers …

A high risk factor for spontaneous and often fatal lobar hemorrhage is cerebral amyloid
angiopathy (CAA). We now report that CAA in an amyloid precursor protein transgenic mouse …

A loss of hippocampal neurons and synapses had been considered a hallmark of normal
aging and, furthermore, to be a substrate of age-related learning and memory deficits. Recent …