User profiles for Michael E. O'Leary

Michael O'Leary

Cooper Medical School of Rowan University
Verified email at rowan.edu
Cited by 2038

Single-cell analysis of sodium channel expression in dorsal root ganglion neurons

C Ho, ME O'Leary - Molecular and Cellular Neuroscience, 2011 - Elsevier
Sensory neurons of the dorsal root ganglia (DRG) express multiple voltage-gated sodium (Na)
channels that substantially differ in gating kinetics and pharmacology. Small-diameter (<…

Role of voltage‐gated sodium, potassium and calcium channels in the development of cocaine‐associated cardiac arrhythmias

ME O'Leary, JC Hancox - British journal of clinical …, 2010 - Wiley Online Library
Cocaine is a highly active stimulant that alters dopamine metabolism in the central nervous
system resulting in a feeling of euphoria that with time can lead to addictive behaviours. …

State‐dependent trapping of flecainide in the cardiac sodium channel

E Ramos, ME O'leary - The Journal of physiology, 2004 - Wiley Online Library
Flecainide is a Class I antiarrhythmic drug and a potent inhibitor of the cardiac (Nav1.5)
sodium channel. Although the flecainide inhibition of Nav1.5 is typically enhanced by …

[HTML][HTML] Animal models of rheumatoid pain: experimental systems and insights

BD Fischer, A Adeyemo, ME O'Leary… - Arthritis research & …, 2017 - Springer
Severe chronic pain is one of the hallmarks and most debilitating manifestations of inflammatory
arthritis. It represents a significant problem in the clinical management of patients with …

Gating properties of Nav1. 7 and Nav1. 8 peripheral nerve sodium channels

K Vijayaragavan, ME O'Leary… - Journal of …, 2001 - Soc Neuroscience
Several distinct components of voltage-gated sodium current have been recorded from native
dorsal root ganglion (DRG) neurons that display differences in gating and pharmacology. …

Dysregulation of Kv3. 4 channels in dorsal root ganglia following spinal cord injury

DM Ritter, BM Zemel, TJ Hala, ME O'Leary… - Journal of …, 2015 - Soc Neuroscience
Spinal cord injury (SCI) patients develop chronic pain involving poorly understood central
and peripheral mechanisms. Because dysregulation of the voltage-gated Kv3.4 channel has …

Regulation of Nav1.6 and Nav1.8 peripheral nerve Na+ channels by auxiliary β-subunits

J Zhao, ME O'Leary, M Chahine - Journal of …, 2011 - journals.physiology.org
Voltage-gated Na + (Na v ) channels are composed of a pore-forming α-subunit and one or
more auxiliary β-subunits. The present study investigated the regulation by the β-subunit of …

Modulation of Kv3. 4 channel N‐type inactivation by protein kinase C shapes the action potential in dorsal root ganglion neurons

DM Ritter, C Ho, ME O'Leary… - The Journal of …, 2012 - Wiley Online Library
Non‐technical summary The orchestrated activity of an ensemble of voltage‐gated ion channels
determines the initiation, shape and duration of the action potential in excitable cells. In …

[HTML][HTML] Regulatory role of voltage-gated Na+ channel β subunits in sensory neurons

M Chahine, ME O'Leary - Frontiers in pharmacology, 2011 - frontiersin.org
Voltage-gated sodium Na + channels are membrane-bound proteins incorporating aqueous
conduction pores that are highly selective for sodium Na + ions. The opening of these …

Regulation/modulation of sensory neuron sodium channels

M Chahine, ME O'Leary - Voltage Gated Sodium Channels, 2014 - Springer
The pseudounipolar sensory neurons of the dorsal root ganglia (DRG) give rise to peripheral
branches that convert thermal, mechanical, and chemical stimuli into electrical signals that …