Pseudomonas aeruginosa is an opportunistic human pathogen that causes a variety of
infections in immunocompromised hosts and individuals with cystic fibrosis. Expression of …

We report the discovery of the lasR gene, which positively regulates elastase expression in
Pseudomonas aeruginosa PAO1. The lasR gene was cloned by its ability to restore a …

Heterozygous mutation or deletion of the ß subunit of platelet-activating factor acetylhydrolase
(PAFAH1B1, also known as LIS1) in humans is associated with type I lissencephaly, a …

Mutations in mammalian Lis1 (Pafah1b1) result in neuronal migration defects. Several lines
of evidence suggest that LIS1 participates in pathways regulating microtubule function, but …

The lasR gene of Pseudomonas aeruginosa is required for transcription of the genes for
elastase (lasB) and LasA protease (lasA), two proteases associated with virulence. We report …

Humans with mutations in either DCX or LIS1 display nearly identical neuronal migration
defects, known as lissencephaly. To define subcellular mechanisms, we have combined in vitro …

Heterozygous deletions of 17p13.3 result in the human neuronal migration disorders
isolated lissencephaly sequence (ILS) and the more severe Miller–Dieker syndrome (MDS). …

Whereas total loss of Lis1 is lethal, disruption of one allele of the Lis1 gene results in brain
abnormalities, indicating that developing neurons are particularly sensitive to a reduction in …

Purpose: The endoplasmic reticulum–associated degradation pathway is responsible for
the translocation of misfolded proteins across the endoplasmic reticulum membrane into the …

Unlike neurons in the central nervous system (CNS), injured neurons in the peripheral
nervous system (PNS) can regenerate their axons and reinnervate their targets. However, …