Individual variation in the addiction liability of amphetamines has a heritable genetic component.
We previously identified Hnrnph1 (heterogeneous nuclear ribonucleoprotein H1) as a …

Binge-drinking is the most prevalent form of alcohol abuse and while an early life history of
binge-drinking is a significant risk factor for subsequent alcoholism and co-morbid affective …

We previously reported that commercially-sourced C57BL/6J (B6) male mice with a history
of adult-onset binge-drinking exhibit anxiety-like behavior in early withdrawal, while the …

Traditionally, a reduction in floating behavior or immobility in the Porsolt forced swim test is
employed as a predictor of anti-depressant efficacy. However, over the past several years, …

Binge alcohol-drinking elicits symptoms of negative affect such as anxiety upon cessation,
which is a source of negative reinforcement for perpetuating this pattern of alcohol abuse. …

The bed nucleus of the stria terminalis (BNST) is part of the limbic-hypothalamic system
important for behavioral responses to stress, and glutamate transmission within this region has …

Withdrawal from binge-drinking increases negative affect, coinciding with increased
expression of the metabotropic glutamate receptor 5 (mGlu5) within the shell of the nucleus …

Opioid abuse in the United States has reached epidemic proportions, with treatment
admissions and deaths associated with prescription opioid abuse quadrupling over the past 10 …

A prior history of excessive drinking induces a negative affective state in both humans and
laboratory rodents, the manifestation of which varies with the age of drinking-onset. In …

Background Hnrnph1 is a validated quantitative trait gene for methamphetamine behavioral
sensitivity that encodes for heterogeneous nuclear ribonucleoprotein H1 (hnRNP H1). This …