The extensive lengths of neuronal processes necessitate efficient mechanisms for communication
with the cell body. Neuronal regeneration after nerve injury requires new transcription; …

Retrograde axonal injury signalling stimulates cell body responses in lesioned peripheral
neurons. The involvement of importins in retrograde transport suggests that transcription …

The regenerative capacity of the injured CNS in adult mammals is severely limited, yet axons
in the peripheral nervous system (PNS) regrow, albeit to a limited extent, after injury. We …

How is protein synthesis initiated locally in neurons? We found that mTOR (mechanistic
target of rapamycin) was activated and then up-regulated in injured axons, owing to local …

Axoplasmic proteins containing nuclear localization signals (NLS) signal retrogradely by an
unknown mechanism in injured nerve. Here we demonstrate that the importin/karyopherin α …

How are phosphorylated kinases transported over long intracellular distances, such as in the
case of axon to cell body signaling after nerve injury? Here, we show that the MAP kinases …

Reactive oxygen species (ROS) contribute to tissue damage and remodelling mediated by
the inflammatory response after injury. Here we show that ROS, which promote axonal …

Peripheral sensory neurons respond to axon injury by activating an importin-dependent
retrograde signaling mechanism. How is this mechanism regulated? Here, we show that Ran …

Hypervariability is a prominent feature of large gene families that mediate interactions
between organisms, such as venom-derived toxins or immunoglobulins. In order to study …

Subcellular localization of mRNA enables compartmentalized regulation within large cells.
Neurons are the longest known cells; however, so far, evidence is lacking for an essential …