Plaques containing β-amyloid (Aβ) peptides are one of the pathological features of Alzheimer's
disease, and the reduction of Aβ is considered a primary therapeutic target. Amyloid …

… We dedicate this work to the memory of Mitsuo Saito, our colleague and friend, whose
contribution to understanding the role of lipids in neurotransmission was unsurpassed. His insight, …

Inhibition of the oxidation of methyl linoleate and soybean phosphatidylcholine in homogeneous
solution and in aqueous dispersion by four chain-breaking antioxidants, vitamin E (…

Autophagy, the major lysosomal pathway for the turnover of intracellular organelles is
markedly impaired in neurons in Alzheimer’s disease and Alzheimer mouse models. We have …

A microorganism with close immunohistological and genetic resemblance toHelicobacter
pylori was found in the resected gallbladder mucosa of a 41-year-old woman. The woman was …

In addition to being the greatest genetic risk factor for Alzheimer's disease, expression of the
ɛ4 allele of apolipoprotein E can lead to cognitive decline during ageing that is …

It is well known that intake of grapefruit juice affects the pharmacokinetics of various kinds of
drugs. It has been reported that other citrus juices also interact with certain drugs. To re-…

Background: Recently, metastasis associated with the colon cancer 1 (MACC1) gene was
identified by genome-wide search for differentially expressed genes in human colon cancer …

Extracellular vesicles (EV), including exosomes, secreted vesicles of endocytic origin, and
microvesicles derived from the plasma membrane, have been widely isolated and …

Background: Recently, it was shown that the Vimentin gene, usually activated in mesenchymal
cells, was highly methylated in colorectal carcinoma. Moreover, Vimentin methylation can …