Patients with antithyroid antibodies are prone to develop destructive thyroiditis by nivolumab: a prospective study

…, D Hagiwara, Y Ito, Y Morishita, M Goto… - Journal of the …, 2018 - academic.oup.com
Context Immune checkpoint inhibitors, including anti–programmed cell death-1 (PD-1)
antibodies, have become promising treatments for a variety of advanced malignancies. However, …

[HTML][HTML] Pituitary dysfunction induced by immune checkpoint inhibitors is associated with better overall survival in both malignant melanoma and non-small cell lung …

…, N Okada, T Okuji, M Ito, T Onoue, M Goto… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Original research: Pituitary dysfunction induced by immune checkpoint inhibitors is associated
with better overall survival in both malignant melanoma and non-small cell lung carcinoma…

Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate …

H Shimizu, H Arima, M Watanabe, M Goto… - …, 2008 - academic.oup.com
Recent studies suggest that the AMP-activated protein kinase (AMPK) signaling in the
hypothalamus is the master regulator of energy balance. We reported in previous studies that …

CD4+ T cells are essential for the development of destructive thyroiditis induced by anti–PD-1 antibody in thyroglobulin-immunized mice

…, Y Ito, H Takagi, D Hagiwara, M Goto… - Science Translational …, 2021 - science.org
Immune-related adverse events induced by anti–programmed cell death–1 antibodies (PD-1-Ab),
including destructive thyroiditis (thyroid-irAE), are thought to be caused by activated T …

Flash glucose monitoring helps achieve better glycemic control than conventional self-monitoring of blood glucose in non-insulin-treated type 2 diabetes: a …

…, R Banno, Y Kuwatsuka, M Ando, M Goto… - BMJ Open Diabetes …, 2020 - drc.bmj.com
Introduction The present study aimed to evaluate the effects of flash glucose monitoring (FGM)
and conventional self-monitoring of blood glucose (SMBG) on glycemic control in patients …

[PDF][PDF] Hypothalamic contribution to pituitary functions is recapitulated in vitro using 3D-cultured human iPS cells

…, Y Ito, H Takagi, D Hagiwara, S Iwama, M Goto… - Cell reports, 2020 - cell.com
The pituitary is a major hormone center that secretes systemic hormones responding to
hypothalamus-derived-releasing hormones. Previously, we reported the independent pituitary …

Insulin inhibits neuropeptide Y gene expression in the arcuate nucleus through GABAergic systems

…, H Arima, N Ozaki, M Watanabe, M Goto… - Journal of …, 2005 - Soc Neuroscience
Neuropeptide Y (NPY) in the arcuate nucleus is an orexigenic hormone of which levels are
regulated by humoral as well as neural signals. In this study, we examined the regulation of …

[HTML][HTML] Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a …

…, Y Yasuda, E Wada, T Onoue, M Goto… - British journal of …, 2020 - nature.com
Background Anti-programmed cell death-1 (PD-1) antibodies can cause thyroid dysfunction.
However, no predictive biomarkers enabling stratification of thyroid dysfunction risk have …

Ghrelin increases neuropeptide Y and agouti-related peptide gene expression in the arcuate nucleus in rat hypothalamic organotypic cultures

M Goto, H Arima, M Watanabe, M Hayashi… - …, 2006 - academic.oup.com
Ghrelin, which was identified from the rat stomach, is a potent stimulant for food intake.
Several lines of evidence suggest that the orexigenic action of ghrelin is mediated via the …

Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: a multicenter, randomized clinical trial

…, H Araki, D Koya, K Kanasaki, Y Oiso, M Goto… - Clinical and …, 2015 - Springer
Background Several studies have demonstrated that spironolactone has an anti-albuminuric
property in diabetic nephropathy. As an adverse event, spironolactone often induces the …