Longer forms of amyloid β protein: implications for the mechanism of intramembrane cleavage by γ-secretase

…, Y Tanimura, G Dolios, N Hirotani… - Journal of …, 2005 - Soc Neuroscience
γ-Cleavage of β-amyloid precursor protein (APP) in the middle of the cell membrane generates
amyloid β protein (Aβ), and ϵ-cleavage, ∼10 residues downstream of the γ-cleavage site…

Truncated carboxyl-terminal fragments of β-amyloid precursor protein are processed to amyloid β-proteins 40 and 42

…, M Morishima-Kawashima, Y Tanimura, N Hirotani… - Biochemistry, 2004 - ACS Publications
We previously showed that β-amyloid precursor protein (APP) is cleaved not only in the
middle of the membrane (γ-cleavage) but also at novel cleavage sites close to the membrane/…

[HTML][HTML] Blocking the cleavage at midportion between γ-and ε-sites remarkably suppresses the generation of amyloid β-protein

T Sato, Y Tanimura, N Hirotani, TC Saido… - FEBS letters, 2005 - Elsevier
To examine how γ- and ε-cleavages of β-amyloid precursor protein (APP) are related, each
cleavage site was replaced with a stretch of Trp that cannot be cleaved by γ-secretase. …

Poly (β-malic acid) production by the non-growing cells of Aureobasidium sp. strain A-91

T Nakajima-Kambe, N Hirotani, T Nakahara - Journal of fermentation and …, 1996 - Elsevier
Poly(l-malic acid), PM, production by the non-growing cells of Aureobasidium sp. strain A-91
was investigated. Reaction conditions were optimized using non-growing cells of strain A-91…

Interleukin-2 modulates the responsiveness to angiotensin II in cultured vascular smooth muscle cells

…, K Fukuo, S Morimoto, S Kitano, N Momose, A Hirotani… - Atherosclerosis, 1997 - Elsevier
Preincubation with interleukin-2 (IL-2), a T cell-derived cytokine, enhanced the increase in
intracellular Ca 2+ ([Ca 2+ ] i ) induced by angiotensin II (AII) in vascular smooth muscle cells (…

Safety and efficacy of eculizumab in Guillain-Barré syndrome: a multicentre, double-blind, randomised phase 2 trial

…, T Nagashima, T Shimizu, M Hirotani… - The Lancet …, 2018 - thelancet.com
Background Despite the introduction of plasmapheresis and immunoglobulin therapy, many
patients with Guillain-Barré syndrome still have an incomplete recovery. Evidence from …

[BOOK][B] Prosody and LF interpretation: Processing Japanese wh-questions

M Hirotani - 2005 - search.proquest.com
This thesis investigates how prosodic phrasing influences listeners' interpretation of scopally
ambiguous wh-questions in Japanese. It focuses on sentences such as that in (1), in which …

Atorvastatin ameliorates cardiac fibrosis and improves left ventricular diastolic function in hypertensive diastolic heart failure model rats

…, T Iwasaku, A Eguchi, H Sawada, S Hirotani… - Journal of …, 2014 - journals.lww.com
Objective: Clinical studies have suggested the beneficial effects of statin therapy on diastolic
heart failure. However, the mechanism of the beneficial effects of statin on diastolic heart …

Dietary iron restriction prevents hypertensive cardiovascular remodeling in Dahl salt-sensitive rats

Y Naito, S Hirotani, H Sawada, H Akahori, T Tsujino… - …, 2011 - Am Heart Assoc
Iron accumulation is associated with the pathogenesis of several cardiovascular diseases.
However, the preventive effects of iron restriction (IR) against cardiovascular disease remain …

[PDF][PDF] Constraints on prosodic structures in grammar and parser: Scrambled and unscrambled sentences in Japanese

M Hirotani - University of Massachusetts Occasional Papers in …, 2005 - researchgate.net
This paper will explore the prosodic phrasing of scrambled sentences in Japanese.
Specifically, it investigates constraints that can account for the prosodic structure of scrambled …