Breathing must be tightly coordinated with other behaviours such as vocalization, swallowing,
and coughing. These behaviours occur after inspiration, during a respiratory phase termed …

The preBötzinger Complex (preBötC), a medullary network critical for breathing, relies on
excitatory interneurons to generate the inspiratory rhythm. Yet, half of preBötC neurons are …

Opioid-induced respiratory depression (OIRD) represents the primary cause of death associated
with therapeutic and recreational opioid use. Within the United States, the rate of death …

Sighs prevent the collapse of alveoli in the lungs, initiate arousal under hypoxic conditions,
and are an expression of sadness and relief. Sighs are periodically superimposed on normal …

Rhythmicity is a universal timing mechanism in the brain, and the rhythmogenic mechanisms
are generally dynamic. This is illustrated for the neuronal control of breathing, a behavior …

Parabrachial CGRP neurons receive diverse threat-related signals and contribute to
multiple phases of adaptive threat responses in mice, with their inactivation attenuating both …

The analgesic utility of opioid-based drugs is limited by the life-threatening risk of
respiratory depression. Opioid-induced respiratory depression (OIRD), mediated by the m-opioid …

Symmetric, progressive, necrotizing lesions in the brainstem are a defining feature of Leigh
syndrome (LS). A mechanistic understanding of the pathogenesis of these lesions has been …

The ability of neuronal networks to reconfigure is a key property underlying behavioral
flexibility. Networks with recurrent topology are particularly prone to reconfiguration through …

Breathing is regulated automatically by neural circuits in the medulla to maintain homeostasis,
but breathing is also modified by behavior and emotion. Mice have rapid breathing …