The pedunculopontine nucleus is composed of cholinergic and non‐cholinergic neurones
and is located in the caudal pontomesencephalic tegmentum. Evidence suggests that the …

Response inhibition as measured during a stop-signal task refers to the ability to halt an
action that has already been set in motion. Cortical and sub-cortical structures, such as the …

… Nicola J Ray , Nicola J Ray … It is a public-private partnership funded by the Michael J. Fox
Foundation for Parkinson’s research and funding partners, a full list of whom can be found at …

The subthalamic nucleus (STN) is a key node in the network that supports response inhibition.
It is suggested that the STN rapidly inhibits basal ganglia activity, to pause motor output …

Impulse control disorders such as pathological gambling (PG) are a serious and common
adverse effect of dopamine (DA) replacement medication in Parkinson's disease (PD). Patients …

Purpose of Review Although the cholinergic hypothesis of dementia provided a successful
paradigm for the development of new drugs for dementia, this hypothesis has waned in …

Patients who have dementia with Lewy bodies and Alzheimer’s disease show early degeneration
of the cholinergic nucleus basalis of Meynert. However, how white matter projections …

The control of impulse behavior is a multidimensional concept subdivided into separate
subcomponents, which are thought to represent different underlying mechanisms due to either …

Developmental dyslexia is diagnosed when children fail to acquire literacy skills despite
adequate education and intellectual ability. There is evidence of impaired implicit learning in …

Background Gait disturbance is an early, disabling feature of Parkinson's disease (PD) that
is typically refractory to dopaminergic medication. The cortical cholinergic system, originating …