Activity-dependent dendritic release of BDNF and biological consequences

N Kuczewski, C Porcher, V Lessmann, I Medina… - Molecular …, 2009 - Springer
Network construction and reorganization is modulated by the level and pattern of synaptic
activity generated in the nervous system. During the past decades, neurotrophins, and in …

Backpropagating action potentials trigger dendritic release of BDNF during spontaneous network activity

N Kuczewski, C Porcher, N Ferrand… - Journal of …, 2008 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) is a major regulator of activity-dependent synapse
development and plasticity. Because BDNF is a secreted protein, it has been proposed that …

Activity‐dependent dendritic secretion of brain‐derived neurotrophic factor modulates synaptic plasticity

N Kuczewski, C Porcher… - European Journal of …, 2010 - Wiley Online Library
During the last decade, a major role has emerged for brain‐derived neurotrophic factor (BDNF)
in the translation of intrinsic or sensory‐driven synaptic activities into the neuronal …

GABAB receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses

H Fiorentino, N Kuczewski, D Diabira… - Journal of …, 2009 - Soc Neuroscience
GABA, the main inhibitory neurotransmitter in the adult brain, has recently emerged as an
important signal in network development. Most of the trophic functions of GABA have been …

Action of the noradrenergic system on adult-born cells is required for olfactory learning in mice

MM Moreno, K Bath, N Kuczewski… - Journal of …, 2012 - Soc Neuroscience
We have previously shown that an experience-driven improvement in olfactory discrimination
(perceptual learning) requires the addition of newborn neurons in the olfactory bulb (OB). …

Topographical representation of odor hedonics in the olfactory bulb

F Kermen, M Midroit, N Kuczewski, J Forest… - Nature …, 2016 - nature.com
Hedonic value is a dominant aspect of olfactory perception. Using optogenetic manipulation
in freely behaving mice paired with immediate early gene mapping, we demonstrate that …

Opto nongenetics inhibition of neuronal firing

…, M Canepari, G Laverne, N Kuczewski - European Journal of …, 2019 - Wiley Online Library
Optogenetics is based on the selective expression of exogenous opsins by neurons allowing
experimental control of their electrical activity using visible light. The interpretation of the …

Muscarinic acetylcholine receptor knockout mice show distinct synaptic plasticity impairments in the visual cortex

N Origlia, N Kuczewski, E Aztiria… - The Journal of …, 2006 - Wiley Online Library
In the present report, we focused our attention on the role played by the muscarinic acetylcholine
receptors (mAChRs) in different forms of long‐term synaptic plasticity. Specifically, we …

Mechanism of GABAB receptor‐induced BDNF secretion and promotion of GABAA receptor membrane expression

N Kuczewski, C Fuchs, N Ferrand… - Journal of …, 2011 - Wiley Online Library
Mechanism of GABAB receptor‐induced BDNF secretion and promotion of GABAA receptor
membrane expression - Kuczewski - 2011 - Journal of Neurochemistry - Wiley Online …

Spontaneous glutamatergic activity induces a BDNF‐dependent potentiation of GABAergic synapses in the newborn rat hippocampus

N Kuczewski, A Langlois, H Fiorentino… - The Journal of …, 2008 - Wiley Online Library
Spontaneous ongoing synaptic activity is thought to play an instructive role in the maturation
of the neuronal circuits. However the type of synaptic activity involved and how this activity …