The developmental origin of oligodendrocyte progenitors (OLPs) in the forebrain has been
controversial. We now show, by Cre-lox fate mapping in transgenic mice, that the first OLPs …

Platelet-derived growth factor α receptor (PDGFRA)/NG2–expressing glia are distributed
throughout the adult CNS. They are descended from oligodendrocyte precursors (OLPs) in the …

The neck and shoulder region of vertebrates has undergone a complex evolutionary history.
To identify its underlying mechanisms we map the destinations of embryonic neural crest …

After central nervous system (CNS) demyelination—such as occurs during multiple sclerosis—there
is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes …

Oligodendrocyte precursors first arise in a restricted ventral part of the embryonic spinal
cord and migrate laterally and dorsally from there. Later, secondary sources develop in the …

Astrocytes, the most abundant cell population in the central nervous system (CNS), are
essential for normal neurological function. We show that astrocytes are allocated to spatial …

Cortical pyramidal cells are generated from pallial neuroepithelial precursors, whereas
GABAergic interneurons originate in subpallial germinal zones and migrate tangentially to reach …

The enteric nervous system (ENS) in mammals forms from neural crest cells during
embryogenesis and early postnatal life. Nevertheless, multipotent progenitors of the ENS can be …

We determined the embryonic origins of adult forebrain subventricular zone (SVZ) stem
cells by Cre-lox fate mapping in transgenic mice. We found that all parts of the telencephalic …

In the gray matter of the brain, astrocytes have been suggested to export lactate (derived
from glucose or glycogen) to neurons to power their mitochondria. In the white matter, lactate …