Signaling through G protein-coupled receptors (GPCRs) underlies many cellular processes,
yet it is not known which molecules determine the duration of signaling in intact cells. Two …

We have demonstrated, for the first time that microvesicles, a sub-type of extracellular
vesicles (EVs) derived from hCMEC/D3: a human brain endothelial cell (BEC) line transfer …

Every year in the United States, millions of individuals incur ischemic brain injury from stroke,
cardiac arrest, or traumatic brain injury (TBI). These forms of acquired brain injury can lead …

The calcium-permeable transient receptor potential M2 (TRPM2) ion channel is activated
following oxidative stress and has been implicated in ischemic damage; however, little …

The activation of G protein-coupled receptors results in a cascade of events that include acute
signaling, desensitization, and internalization, and it is thought that not all agonists affect …

Chronic treatment with morphine results in a decrease in μ-opioid receptor sensitivity, an
increase in acute desensitization, and a reduction in the recovery from acute desensitization in …

Objective Dexmedetomidine, an α-2a adrenergic agonist, given pre- and postoperatively
was previously shown to attenuate neuronal injury in a murine model of spinal cord ischemia-…

The calcium-permeable transient receptor potential M2 (TRPM2) ion channel was recently
demonstrated to have a sexually dimorphic contribution to ischemic brain injury, with …

Four CaMKII isoforms are encoded by distinct genes, and alternative splicing within the
variable linker-region generates additional diversity. The α and β isoforms are largely brain-…

Introduction TRPM2 channels have been suggested to play a role in ischemic neuronal injury,
specifically in males. A major hindrance to TRPM2 research has been the lack of specific …