In adult mammalian brain, occurrence of the synthesis of estradiol from endogenous cholesterol
has been doubted because of the inability to detect dehydroepiandrosterone synthase, …

Sex hormones are essential for neural circuit development and sex-specific behaviors. Male
behaviors require both testosterone and estrogen, but it is unclear how the two hormonal …

Much evidence indicates that women have a higher risk of developing Alzheimer's disease (AD)
than do men. The reason for this gender difference is unclear. We hypothesize that …

Extensive screening of aromatase cDNA was carried out in cDNA libraries from various human
tissues. The DNA sequences of all the isolated cDNA clones were identical in the region …

Aromatase is known to be involved in the control of morphological, neuroendocrine, and
behavioral sex differences in the brain. To study the detailed functions of aromatase in mouse …

Dioxins exert a variety of adverse effects on organisms, including teratogenesis,
immunosuppression, tumor promotion, and estrogenic action. Studies using aryl hydrocarbon …

The expression of aromatase, the enzyme that catalyzes the biosynthesis of estrogens from
precursor androgens, is increased in the brain after injury, suggesting that aromatase may …

Testosterone and estrogen are essential for male behaviors in vertebrates. How these two
signaling pathways interact to control masculinization of the brain and behavior remains to be …

Intraneuronal production of estradiol from testosterone has been shown to play a pivotal role
in gender-specific brain development of most vertebrates, and to participate in numerous …

We used estrogen-deficient aromatase knock-out (ArKO) mice to determine whether estrogens
contribute to the development of the brain and behavior in females. Female mice of three …