[HTML][HTML] Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
Y Yoshiyama, M Higuchi, B Zhang, SM Huang, N Iwata… - Neuron, 2007 - cell.com
Filamentous tau inclusions are hallmarks of Alzheimer's disease (AD) and related tauopathies,
but earlier pathologies may herald disease onset. To investigate this, we studied wild-…
but earlier pathologies may herald disease onset. To investigate this, we studied wild-…
Metabolic regulation of brain Aβ by neprilysin
N Iwata, S Tsubuki, Y Takaki, K Shirotani, B Lu… - Science, 2001 - science.org
Amyloid β peptide (Aβ), the pathogenic agent of Alzheimer's disease (AD), is a
physiological metabolite in the brain. We examined the role of neprilysin, a candidate Aβ-degrading …
physiological metabolite in the brain. We examined the role of neprilysin, a candidate Aβ-degrading …
Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition
N Iwata, S Tsubuki, Y Takaki, K Watanabe… - Nature medicine, 2000 - nature.com
Alzheimer amyloid β-peptide (Aβ) is a physiological peptide constantly anabolized and
catabolized under normal conditions. We investigated the mechanism of catabolism by tracing …
catabolized under normal conditions. We investigated the mechanism of catabolism by tracing …
Single App knock-in mouse models of Alzheimer's disease
…, N Mihira, J Takano, P Nilsson, S Itohara, N Iwata… - Nature …, 2014 - nature.com
Experimental studies of Alzheimer's disease have largely depended on transgenic mice
overexpressing amyloid precursor protein (APP). These mice, however, suffer from artificial …
overexpressing amyloid precursor protein (APP). These mice, however, suffer from artificial …
[PDF][PDF] Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness
…, WL Klein, H Mori, T Asada, R Takahashi, N Iwata… - Cell stem cell, 2013 - cell.com
Oligomeric forms of amyloid-β peptide (Aβ) are thought to play a pivotal role in the
pathogenesis of Alzheimer's disease (AD), but the mechanism involved is still unclear. Here, we …
pathogenesis of Alzheimer's disease (AD), but the mechanism involved is still unclear. Here, we …
[PDF][PDF] Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls
…, M Ono, K Masamoto, H Takano, N Sahara, N Iwata… - Neuron, 2013 - cell.com
Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms
of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have …
of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have …
[PDF][PDF] Aβ secretion and plaque formation depend on autophagy
…, Y Matsuba, K Hui, S Tsubuki, M Tanaka, N Iwata… - Cell reports, 2013 - cell.com
Alzheimer's disease (AD) is a neurodegenerative disease biochemically characterized by
aberrant protein aggregation, including amyloid beta (Aβ) peptide accumulation. Protein …
aberrant protein aggregation, including amyloid beta (Aβ) peptide accumulation. Protein …
Somatostatin regulates brain amyloid β peptide Aβ42 through modulation of proteolytic degradation
T Saito, N Iwata, S Tsubuki, Y Takaki, J Takano… - Nature medicine, 2005 - nature.com
Expression of somatostatin in the brain declines during aging in various mammals including
apes and humans 1 , 2 . A prominent decrease in this neuropeptide also represents a …
apes and humans 1 , 2 . A prominent decrease in this neuropeptide also represents a …
19F and 1H MRI detection of amyloid β plaques in vivo
M Higuchi, N Iwata, Y Matsuba, K Sato… - Nature …, 2005 - nature.com
Formation of senile plaques composed of amyloid β peptide, a pathological hallmark of
Alzheimer disease, in human brains precedes disease onset by many years. Noninvasive …
Alzheimer disease, in human brains precedes disease onset by many years. Noninvasive …
[HTML][HTML] Neprilysin degrades both amyloid β peptides 1–40 and 1–42 most rapidly and efficiently among thiorphan-and phosphoramidon-sensitive endopeptidases
K Shirotani, S Tsubuki, N Iwata, Y Takaki… - Journal of Biological …, 2001 - ASBMB
To identify the amyloid β peptide (Aβ) 1–42-degrading enzyme whose activity is inhibited by
thiorphan and phosphoramidon in vivo, we searched for neprilysin (NEP) homologues and …
thiorphan and phosphoramidon in vivo, we searched for neprilysin (NEP) homologues and …