User profiles for O. Reiner
 | Orly ReinerProfessor, Incumbent of the Berstein-Mason professorial chair of Neurochemistry, Weizmann … Verified email at weizmann.ac.il Cited by 14889 |
Lissencephaly: a human brain malformation associated with deletion of the LIS1 gene located at chromosome 17p13
Objective. —We review the clinical phenotype, pathological changes, and results of cytogenetic
and molecular genetic studies in 90 probands with lissencephaly (smooth brain) with …
and molecular genetic studies in 90 probands with lissencephaly (smooth brain) with …
A nomenclature consensus for nervous system organoids and assembloids
Self-organizing three-dimensional cellular models derived from human pluripotent stem
cells or primary tissue have great potential to provide insights into how the human nervous …
cells or primary tissue have great potential to provide insights into how the human nervous …
Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
Fragile X syndrome is the most frequent form of inherited mental retardation and is associated
with a fragile site at Xq27. 3. We identified human YAC clones that span fragile X site-…
with a fragile site at Xq27. 3. We identified human YAC clones that span fragile X site-…
Regulation of neuronal migration, an emerging topic in autism spectrum disorders
Autism spectrum disorders ( ASD ) encompass a group of neurodevelopmental diseases
that demonstrate strong heritability, however, the inheritance is not simple and many genes …
that demonstrate strong heritability, however, the inheritance is not simple and many genes …
Isolation of a Miller–Dicker lissencephaly gene containing G protein β-subunit-like repeats
O Reiner, R Carrozzo, Y Shen, M Wehnert… - Nature, 1993 - nature.com
… O'Keefe and S. Jansa for technical assistance. This publication was supported by a NSF grant
… Filters were washed at high stringency (65 C, O.1 x SSC) and exposed to Kodak X-ray film …
… Filters were washed at high stringency (65 C, O.1 x SSC) and exposed to Kodak X-ray film …
[HTML][HTML] Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons
…, MC Vinet, G Friocourt, N McDonnell, O Reiner… - Neuron, 1999 - cell.com
Recently, we and others reported that the doublecortin gene is responsible for X-linked
lissencephaly and subcortical laminar heterotopia. Here, we show that Doublecortin is expressed …
lissencephaly and subcortical laminar heterotopia. Here, we show that Doublecortin is expressed …
The human glucocerebrosidase gene and pseudogene: structure and evolution
M Horowitz, S Wilder, Z Horowitz, O Reiner, T Gelbart… - Genomics, 1989 - Elsevier
We report the sequence of the entire human gene encoding β-glucocerebrosidase and that
of the associated pseudogene. The gene contains 11 exons extending from base pair 355 to …
of the associated pseudogene. The gene contains 11 exons extending from base pair 355 to …
Human brain organoids on a chip reveal the physics of folding
Human brain wrinkling has been implicated in neurodevelopmental disorders and yet its
origins remain unknown. Polymer gel models suggest that wrinkling emerges spontaneously …
origins remain unknown. Polymer gel models suggest that wrinkling emerges spontaneously …
Doublecortin, a stabilizer of microtubules
… We have preliminary results indicating that Doublecortin is phosphorylated by c-Abl (O. Reiner,
… Lis1 gene targeting in the mouse demonstrated a direct neuronal migration defect (16; O. …
… Lis1 gene targeting in the mouse demonstrated a direct neuronal migration defect (16; O. …
[HTML][HTML] Reduction of microtubule catastrophe events by LIS1, platelet‐activating factor acetylhydrolase subunit
… enzymatic activity in microtubule preparations (O.Reiner, O.Schmuel and T.Sapir, … and
the higher concentration of LIS1 in comparison with the α1 and α2 PAF‐AH subunits (O.…
the higher concentration of LIS1 in comparison with the α1 and α2 PAF‐AH subunits (O.…