Glucocorticoids (GCs) exert their anti-inflammatory andimmunosuppressive effects by inhibiting
the expression of cytokines andadhesion molecules. The molecular basis of GC action …

Neuropathic pain is a debilitating clinical condition with few efficacious treatments, warranting
development of novel therapeutics. We hypothesized that dysregulated translation …

Despite the emergence of translational control pathways as mediators of nociceptive
sensitization, effector molecules and mechanisms responsible for modulating activity in these …

Background: Despite advances in our understanding of basic mechanisms driving post-surgical
pain, treating incision-induced pain remains a major clinical challenge. Moreover, …

Although a variety of industrial chemicals, as well as several chemotherapeutic agents used
to treat cancer or HIV, preferentially induce a peripheral sensory neuropathy what remains …

Background: Migraine headache is one of the most common neurological disorders, but the
pathophysiology contributing to migraine is poorly understood. Intracranial interleukin-6 (IL-6…

Sensitization of the pain pathway is believed to promote clinical pain disorders. We hypothesized
that the persistence of a sensitized state in the spinal dorsal horn might depend on the …

Injury-induced sensitization of nociceptors contributes to pain states and the development of
chronic pain. Inhibiting activity-dependent mRNA translation through mechanistic target of …

Mammalian target of rapamycin complex 1 (mTORC1) inhibitors are extensively used as
immunosuppressants to prevent transplant rejection and in treatment of certain cancers. In …

Transcriptional regulation of genes by cyclic AMP response element binding protein (CREB)
is essential for the maintenance of long-term memory. Moreover, retrograde axonal …