Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed by
perisynaptic astroglial processes (PAPs): this helps maintain point-to-point transmission in …

Spinal cord GluR2-lacking AMPA receptors (AMPARs) contribute to nociceptive
hypersensitivity in persistent pain, but the molecular mechanisms underlying this event are not …

Brain cells continuously produce and release protons into the extracellular space, with the
rate of acid production corresponding to the levels of neuronal activity and metabolism. …

Mutations in the SNCA gene cause autosomal dominant Parkinson’s disease (PD), with
loss of dopaminergic neurons in the substantia nigra, and aggregation of α-synuclein. The …

Introduction The second most common form of early‐onset dementia—frontotemporal dementia
(FTD)—is often characterized by the aggregation of the microtubule‐associated protein …

Peripheral inflammation alters AMPA receptor (AMPAR) subunit trafficking and increases
AMPAR Ca 2+ permeability at synapses of spinal dorsal horn neurons. However, it is unclear …

Activity-dependent remodeling of excitatory connections underpins memory formation in the
brain. Serotonin receptors are known to contribute to such remodeling, yet the underlying …

Brain ischemic stroke is among the leading causes of death and long-term disability. New
treatments that alleviate brain cell damage until blood supply is restored are urgently required. …

The dorsal horn (DH) neurons of the spinal cord play a critical role in nociceptive input
integration and processing in the central nervous system. Engaged neuronal classes and cell-…

Human iPSC lines represent a powerful translational model of tauopathies. We have recently
described a pathophysiological phenotype of neuronal excitability of human cells derived …