[PDF][PDF] Altered activity of the locus coeruleus in an animal model of depression

PE Simson, JM Weiss - Neuropsychopharmacology, 1988 - researchgate.net
… of the No-stress group were simply placed in the apparatus without shock for equivalent pe-
… irregular firing rate, including the spontaneous burst of activity followed by a quiescent pe- …

Molecular basis for regionally specific action of ethanol on gamma-aminobutyric acidA receptors: generalization to other ligand-gated ion channels.

HE Criswell, PE Simson, GE Duncan… - … of Pharmacology and …, 1993 - ASPET
The present investigation provides evidence that there is neuroanatomical specificity for
ethanol enhancement of gamma-aminobutyric acid (GABA)-induced inhibition in mammalian …

Ethanol inhibits NMDA-evoked electrophysiological activity in vivo.

PE Simson, HE Criswell, KB Johnson, RE Hicks… - … of Pharmacology and …, 1991 - ASPET
Recent studies have demonstrated that ethanol blocks N-methyl-D-aspartate (NMDA)
responses in vitro. In the present study, evidence is provided that ethanol, when administered by …

Neurochemical and electrophysiological events underlying stress-induced depression in an animal model

JM Weiss, PE Simson - Mechanisms of physical and emotional stress, 1988 - Springer
Exposing rats to uncontrollable shock produces behavioral and vegetative changes which
bear considerable similarity to what is seen in human depression. This particular procedure …

Acute ethanol impairs spatial memory but not stimulus/response memory in the rat

DB Matthews, PE Simson… - Alcoholism: Clinical and …, 1995 - Wiley Online Library
The present studies investigate how acutely administered ethanol (ETOH) affects the use of
spatial memory. Previous electrophysiological results have shown that acutely administered …

Dopamine electrophysiology of ventral pallidal/substantia innominata neurons: comparison with the dorsal globus pallidus.

TC Napier, PE Simson, BS Givens - Journal of Pharmacology and …, 1991 - ASPET
The ventral pallidum/substantia innominata (VP/SI) is an infracommissural extension of the
dorsal globus pallidus (GP). Functional studies suggest that the VP/SI is indirectly influenced …

Inhibition of NMDA-evoked electrophysiological activity by ethanol in selected brain regions: evidence for ethanol-sensitive and ethanol-insensitive NMDA-evoked …

PE Simson, HE Criswell, GR Breese - Brain research, 1993 - Elsevier
Our laboratory has previously shown that systemically administered ethanol inhibits NMDA-evoked
electrophysiological activity in some, but not all, neurons in the medial septum. In the …

Intracerebroventricular infusion of interleukin 1 rapidly decreases peripheral cellular immune responses.

…, SL Fleener, JC Ritchie, PE Simson… - Proceedings of the …, 1989 - National Acad Sciences
Low doses (50-200 pg or 3.1-12.4 fmol) of interleukin 1 (IL-1) infused into the brain of rats
produced rapid suppression of various cellular immune responses in peripheral lymphocytes …

Alpha-2 receptor blockade increases responsiveness of locus coeruleus neurons to excitatory stimulation

PE Simson, JM Weiss - Journal of Neuroscience, 1987 - Soc Neuroscience
This study presents evidence that alpha 2-receptors in the locus coeruleus (LC) regulate the
responsiveness of LC neurons to excitatory stimuli. In the first experiment, intravenous …

Comparison between the effects of ethanol and diazepam on spatial working memory in the rat

AM White, PE Simson, PJ Best - Psychopharmacology, 1997 - Springer
The present study compared the effects of ethanol and diazepam on a task that allows for
the assessment of both spatial working memory and the acquisition of spatial information …