Phosphacan, a chondroitin sulfate proteoglycan of brain that interacts with neurons and neural cell-adhesion molecules, is an extracellular variant of a receptor-type …

P Maurel, U Rauch, M Flad… - Proceedings of the …, 1994 - National Acad Sciences
We have identified cDNA clones encoding a chondroitin sulfate proteoglycan of rat brain (previously
designated 3F8 and now named phosphacan) that binds to neurons and neural cell-…

Axonal regulation of Schwann cell proliferation and survival and the initial events of myelination requires PI 3-kinase activity

P Maurel, JL Salzer - Journal of Neuroscience, 2000 - Soc Neuroscience
In this report, we have investigated the signaling pathways that are activated by, and mediate
the effects of, the neuregulins and axonal contact in Schwann cells. Phosphatidylinositol 3-…

Differential regulation of expression of hyaluronan-binding proteoglycans in developing brain: aggrecan, versican, neurocan, and brevican

P Milev, P Maurel, A Chiba, M Mevissen, S Popp… - Biochemical and …, 1998 - Elsevier
We have used a slot-blot radioimmunoassay to quantitate the levels of hyaluronan-binding
chondroitin sulfate proteoglycans in developing rat brain from embryonic day 14 (E 14) to …

Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain.

U Rauch, L Karthikeyan, P Maurel, RU Margolis… - Journal of Biological …, 1992 - ASBMB
We have obtained the complete coding sequence of neurocan, a chondroitin sulfate
proteoglycan of rat brain which is developmentally regulated with respect to its molecular size, …

Nectin-like proteins mediate axon–Schwann cell interactions along the internode and are essential for myelination

P Maurel, S Einheber, J Galinska, P Thaker… - The Journal of cell …, 2007 - rupress.org
Axon–glial interactions are critical for the induction of myelination and the domain organization
of myelinated fibers. Although molecular complexes that mediate these interactions in the …

Soluble neuregulin-1 has bifunctional, concentration-dependent effects on Schwann cell myelination

…, DP Yang, C Taveggia, JL Salzer, P Maurel… - Journal of …, 2010 - Soc Neuroscience
Members of the neuregulin-1 (Nrg1) growth factor family play important roles during Schwann
cell development. Recently, it has been shown that the membrane-bound type III isoform is …

p38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination

…, T Mindos, R Mirsky, KR Jessen, P Maurel… - Journal of …, 2012 - Soc Neuroscience
Physical damage to the peripheral nerves triggers Schwann cell injury response in the distal
nerves in an event termed Wallerian degeneration: the Schwann cells degrade their myelin …

Neurocan and phosphacan: two major nervous tissue-specific chondroitin sulfate proteoglycans.

RK Margolis, U Rauch, P Maurel… - Perspectives on …, 1996 - europepmc.org
Neurocan is a multidomain hyaluronan-binding chondroitin sulfate proteoglycan that is
synthesized by neurons, whereas the astroglial proteoglycan phosphacan is an mRNA splice …

[HTML][HTML] TAG-1/axonin-1 is a high-affinity ligand of neurocan, phosphacan/protein-tyrosine phosphatase-ζ/β, and N-CAM

P Milev, P Maurel, M Häring, RK Margolis… - Journal of Biological …, 1996 - ASBMB
Proteoglycans appear to play an important role in modulating cell-cell and cell-matrix
interactions during nervous tissue histogenesis. The nervous tissue-specific chondroitin sulfate …

Zeb2 recruits HDAC–NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination

…, Z Ford, L Zhang, C Zweier, BG Ayee, P Maurel… - Nature …, 2016 - nature.com
The mechanisms that coordinate and balance a complex network of opposing regulators to
control Schwann cell (SC) differentiation remain elusive. Here we demonstrate that zinc-…