User profiles for Patrick A. Lewis
Patrick A. LewisRoyal Veterinary College Verified email at rvc.ac.uk Cited by 24646 |
Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences
Advances in the technologies and informatics used to generate and process large biological
data sets (omics data) are promoting a critical shift in the study of biomedical sciences. …
data sets (omics data) are promoting a critical shift in the study of biomedical sciences. …
[HTML][HTML] Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
A major barrier to research on Parkinson's disease is inaccessibility of diseased tissue for
study. One solution is to derive induced pluripotent stem cells from patients and differentiate …
study. One solution is to derive induced pluripotent stem cells from patients and differentiate …
The Parkinson's disease–linked proteins Fbxo7 and Parkin interact to mediate mitophagy
Compelling evidence indicates that two autosomal recessive Parkinson's disease genes,
PINK1 (PARK6) and Parkin (PARK2), cooperate to mediate the autophagic clearance of …
PINK1 (PARK6) and Parkin (PARK2), cooperate to mediate the autophagic clearance of …
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
Mutations in Leucine Rich Repeat Kinase 2 (LRRK2) are the leading genetic cause of
Parkinson’s disease (PD). LRRK2 is predicted to contain kinase and GTPase enzymatic domains, …
Parkinson’s disease (PD). LRRK2 is predicted to contain kinase and GTPase enzymatic domains, …
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of Parkinson's
disease (PD). LRRK2 contains a Ras of complex proteins (ROC) domain that may act as a …
disease (PD). LRRK2 contains a Ras of complex proteins (ROC) domain that may act as a …
Identification of candidate Parkinson disease genes by integrating genome-wide association study, expression, and epigenetic data sets
Importance Substantial genome-wide association study (GWAS) work in Parkinson disease (PD)
has led to the discovery of an increasing number of loci shown reliably to be associated …
has led to the discovery of an increasing number of loci shown reliably to be associated …
Genetic and phenotypic characterization of complex hereditary spastic paraplegia
The hereditary spastic paraplegias are a heterogeneous group of degenerative disorders
that are clinically classified as either pure with predominant lower limb spasticity, or complex …
that are clinically classified as either pure with predominant lower limb spasticity, or complex …
[HTML][HTML] Inhibition of LRRK2 kinase activity stimulates macroautophagy
Leucine Rich Repeat Kinase 2 (LRRK2) is one of the most important genetic contributors to
Parkinson's disease. LRRK2 has been implicated in a number of cellular processes, …
Parkinson's disease. LRRK2 has been implicated in a number of cellular processes, …
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration
…, A Lees, JC Troncoso, PA Lewis… - Human molecular …, 2014 - academic.oup.com
Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus,
encoding a key component of the retromer complex, were recently identified as a new cause of …
encoding a key component of the retromer complex, were recently identified as a new cause of …
[HTML][HTML] Cancer and neurodegeneration: between the devil and the deep blue sea
H Plun-Favreau, PA Lewis, J Hardy, LM Martins… - PLoS …, 2010 - journals.plos.org
Cancer and neurodegeneration are often thought of as disease mechanisms at opposite
ends of a spectrum; one due to enhanced resistance to cell death and the other due to …
ends of a spectrum; one due to enhanced resistance to cell death and the other due to …