Advances in the technologies and informatics used to generate and process large biological
data sets (omics data) are promoting a critical shift in the study of biomedical sciences. …

A major barrier to research on Parkinson's disease is inaccessibility of diseased tissue for
study. One solution is to derive induced pluripotent stem cells from patients and differentiate …

Compelling evidence indicates that two autosomal recessive Parkinson's disease genes,
PINK1 (PARK6) and Parkin (PARK2), cooperate to mediate the autophagic clearance of …

Mutations in Leucine Rich Repeat Kinase 2 (LRRK2) are the leading genetic cause of
Parkinson’s disease (PD). LRRK2 is predicted to contain kinase and GTPase enzymatic domains, …

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of Parkinson's
disease (PD). LRRK2 contains a Ras of complex proteins (ROC) domain that may act as a …

Importance Substantial genome-wide association study (GWAS) work in Parkinson disease (PD)
has led to the discovery of an increasing number of loci shown reliably to be associated …

The hereditary spastic paraplegias are a heterogeneous group of degenerative disorders
that are clinically classified as either pure with predominant lower limb spasticity, or complex …

Leucine Rich Repeat Kinase 2 (LRRK2) is one of the most important genetic contributors to
Parkinson's disease. LRRK2 has been implicated in a number of cellular processes, …

Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus,
encoding a key component of the retromer complex, were recently identified as a new cause of …

Cancer and neurodegeneration are often thought of as disease mechanisms at opposite
ends of a spectrum; one due to enhanced resistance to cell death and the other due to …