Dietary protocols that increase serum levels of ketones, such as calorie restriction and the
ketogenic diet, offer robust protection against a multitude of acute and chronic neurological …

Fatty acids are known to enhance mitochondrial uncoupling protein (UCP) activity. We asked
whether a high‐fat ketogenic diet (KD) increases UCP levels and activity in hippocampi of …

Recent evidence suggests that intracellular Zn 2+ accumulation contributes to the neuronal
injury that occurs in epilepsy or ischemia in certain brain regions, including hippocampus, …

Creatine, one of the most common food supplements used by individuals at almost every
level of athleticism, promote gains in performance, strength, and fat‐free mass. Recent …

Experimental traumatic brain injury (TBI) results in a rapid and significant necrosis of cortical
tissue at the site of injury. In the ensuring hours and days, secondary injury exacerbates the …

In the present study, we investigate the hypothesis that mitochondrial oxidative damage and
dysfunction precede the onset of neuronal loss after controlled cortical impact traumatic …

Evidence suggests that chronic inflammation, mitochondrial dysfunction, and oxidative
stress play significant and perhaps synergistic roles in Parkinson’s disease (PD), where the …

Traumatic brain injury (TBI) as a consequence of exposure to blast is increasingly prevalent
in military populations, with the underlying pathophysiological mechanisms mostly unknown. …

The present study examined the neuropathology of the lateral controlled cortical impact (CCI)
traumatic brain injury (TBI) model in mice utilizing the de Olmos silver staining method that …

Rapid entry of Ca 2+ or Zn 2+ kills neurons. Mitochondria are major sites of Ca 2+ -dependent
toxicity. This study examines Zn 2+ -initiated mitochondrial cell death signaling. 10 nm Zn …