In Saccharomyces cerevisiae, meiotic recombination is initiated by Spo11-dependent
double-strand breaks (DSBs), a process that precedes homologous synapsis. Here we use an …

In Neurospora, DNA unpaired in meiosis both is silenced and induces silencing of all DNA
homologous to it. This process, called meiotic silencing by unpaired DNA, is thought to …

We tested the hypothesis that genes encoded on the sex chromosomes play a direct role in
sexual differentiation of brain and behavior. We used mice in which the testis-determining …

The “XY crossover model” described in this paper postulates that (1) the pairing observed
between the X and the Y chromosome at zygotene is a consequence of genetic homology, (2) …

In mammalian spermatogenesis, the X and Y chromosomes are transcriptionally silenced
during the pachytene stage of meiotic prophase (meiotic sex chromosome inactivation, MSCI), …

During mammalian meiosis, synapsis of paternal and maternal chromosomes and the generation
of DNA breaks are needed to allow reshuffling of parental genes. In mammals errors in …

The testes of fetal, prepuberal and adult XX ↔ XY chimaeras were examined using in situ
hybridisation to identify the β -globin transgenic marker contained in one component of each …

Transcriptional silencing of the sex chromosomes during male meiosis (MSCI) is conserved
among organisms with limited sex chromosome synapsis, including mammals. Since the …

A major question is whether genes encoded on the sex chromosomes act directly in non-gonadal
tissues to cause sex differences in development or function, or whether all sex …

Across human cultures and mammalian species, sex differences can be found in the expression
of aggression and parental nurturing behaviors: males are typically more aggressive …