It IS NOW accepted generally that intracellular Ca” is a crucial signal that controls many
aspects of cellular function. Neuronal Ca” signalling is particularly complex; activation of …

Selective modulators of γ-aminobutyric acid, type A (GABA A ) receptors containing α 4 subunits
may provide new treatments for epilepsy and premenstrual syndrome. Using mouse L(−…

We have examined the potential roles of intracellular Ca 2+ regulation and of multiple
cytoskeletal elements in control of the directed migration of cultured oligodendrocyte progenitor …

In oligodendrocyte processes, methacholine-evoked Ca 2+ waves propagate via regions of
specialized Ca 2+ release kinetics (wave amplification sites) at which the amplitude and rate …

Most cancer patients receive chemotherapy at some stage of their treatment which makes
improving the efficacy of cytotoxic drugs an ongoing and important goal. Despite large …

Highlights • Organ-on-a-chip technology has the potential to improve the success of drug
discovery. • Environmental cues and inter-organ communication increase physiological …

To understand how extracellular signals may produce long-term effects in neural cells, we
have analyzed the mechanism by which neurotransmitters and growth factors induce …

It is becoming increasingly clear that mitochondrial Ca 2+ uptake from and release into the
cytosol has important consequences for neuronal and glial activity. Ca 2+ regulates …

We have examined the spatial and temporal nature of Ca 2+ signals activated via the
phosphoinositide pathway in oligodendrocytes and the cellular specializations underlying …

To facilitate the characterization of compounds that have positive growth factor mimetic
effects on neuritogenesis, we have implemented a high-throughput functional assay which …