Astrocytic brain tumours, including glioblastomas, are incurable neoplasms characterized
by diffusely infiltrative growth. Here we show that many tumour cells in astrocytomas extend …

Inefficient T cell migration is a major limitation of cancer immunotherapy. Targeted activation
of the tumor microenvironment may overcome this barrier. We demonstrate that …

PURPOSE: To test the feasibility of noninvasive magnetic resonance (MR) imaging–guided
focused ultrasound surgery (FUS) of benign fibroadenomas in the breast. MATERIALS AND …

It is here demonstrated that the set of gene expressions underlying the angiogenic balance
in tissues can be molecularly reset en masse by a single protein. Using genome-wide …

Pulmonary fibrosis is the consequence of a variety of diseases with no satisfying treatment
option. Therapy-induced fibrosis also limits the efficacy of chemotherapy and radiotherapy in …

An ideal vision of modern medicine includes tumor surgery with the human body remaining
completely intact. A noninvasive therapy could avoid infections and scar formation; it would …

Copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) are prototypic and well-characterized
polymeric drug carriers that have been broadly implemented in the delivery of …

Tumor dormancy has important implications for early detection and treatment of cancer. Lack
of experimental models and limited clinical accessibility constitute major obstacles to the …

The involvement of α v β 3 and α v β 5 integrins in angiogenesis and the use of integrin
antagonists as effective antiangiogenic agents are documented. Radiotherapy is an important …

A shift of the angiogenic balance to the proangiogenic state, termed the “angiogenic switch,”
is a hallmark of cancer progression. Here we devise a strategy for identifying genetic …