Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer
PG Wells, GP McCallum, CS Chen… - Toxicological …, 2009 - academic.oup.com
In the developing embryo and fetus, endogenous or xenobiotic-enhanced formation of
reactive oxygen species (ROS) like hydroxyl radicals may adversely alter development by …
reactive oxygen species (ROS) like hydroxyl radicals may adversely alter development by …
Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity
The sedative drug thalidomide ([+]-alpha-phthalimidoglutarimide), once abandoned for
causing birth defects in humans 1, has found new therapeutic license in leprosy and other …
causing birth defects in humans 1, has found new therapeutic license in leprosy and other …
Glucuronidation and the UDP-glucuronosyltransferases in health and disease
This article is an updated report of a symposium held at the June 2000 annual meeting of
the American Society for Pharmacology and Experimental Therapeutics in Boston. The …
the American Society for Pharmacology and Experimental Therapeutics in Boston. The …
Molecular and biochemical mechanisms in teratogenesis involving reactive oxygen species
PG Wells, Y Bhuller, CS Chen, W Jeng… - Toxicology and applied …, 2005 - Elsevier
Developmental pathologies may result from endogenous or xenobiotic-enhanced formation
of reactive oxygen species (ROS), which oxidatively damage cellular macromolecules and/…
of reactive oxygen species (ROS), which oxidatively damage cellular macromolecules and/…
Polychaetes key taxa for marine environmental quality monitoring
P Pocklington, PG Wells - Marine Pollution Bulletin, 1992 - Elsevier
Polychaetes are used in each of these approches: as bioassay organisms, as monitors for
toxic materials, and as pollution indicators at the various levels. The literature clearly …
toxic materials, and as pollution indicators at the various levels. The literature clearly …
Oxidative damage in chemical teratogenesis
The teratogenicity of many xenobiotics is thought to depend at least in part upon their
bioactivation by embryonic cytochromes P450, prostaglandin H synthase (PHS) and …
bioactivation by embryonic cytochromes P450, prostaglandin H synthase (PHS) and …
A teratologic suppressor role for p53 in benzo(a)pyrene–treated transgenic p53-deficient mice
…, ML Harrison, RR Laposa, IL Gimelshtein, PG Wells - Nature …, 1995 - nature.com
DNA damage may mediate birth defects caused by many drugs and environmental chemicals,
therefore p53, a tumour suppressor gene that facilitates DNA repair, may be critically …
therefore p53, a tumour suppressor gene that facilitates DNA repair, may be critically …
An embryoprotective role for glucose-6-phosphate dehydrogenase in developmental oxidative stress and chemical teratogenesis
…, J Zielenski, LC Tsui, PG Wells - Proceedings of the Korea …, 2002 - koreascience.kr
The primary recognized health risk from common deficiencies in glucose-6-phosphate
dehydrogenase (G6PD), a cytoprotective enzyme for oxidative stress, is red blood cell hemolysis. …
dehydrogenase (G6PD), a cytoprotective enzyme for oxidative stress, is red blood cell hemolysis. …
Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert's syndrome
SMF De Morais, JP Uetrecht, PG Wells - Gastroenterology, 1992 - Elsevier
Gilbert's syndrome occurs in 5%–7% of the human population and is caused by an inherited
deficiency in the glucuronidation of endogenous bilirubin, resulting in its accumulation and …
deficiency in the glucuronidation of endogenous bilirubin, resulting in its accumulation and …
[PDF][PDF] Artemia in aquatic toxicology: a review
G Persoone, PG Wells - Artemia research and its applications, 1987 - vliz.be
Due to the commercial availability of dried cysts from which live test material can be hatched
at will, Artemia is used extensively in research and applied toxicology. Despite the …
at will, Artemia is used extensively in research and applied toxicology. Despite the …