Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation

P Van Lint, C Libert - Journal of Leucocyte Biology, 2007 - academic.oup.com
The action of matrix metalloproteinases (MMPs) was originally believed to be restricted to
degradation of the extracellular matrix; however, in recent years, it has become evident that …

Matrix metalloproteinase-8: cleavage can be decisive

P Van Lint, C Libert - Cytokine & growth factor reviews, 2006 - Elsevier
Matrix metalloproteinase-8 (MMP-8), also known as collagenase-2 or neutrophil collagenase,
was long thought to be expressed solely by maturing neutrophils, and functionally …

Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage

L Tian, M Stefanidakis, L Ning, P Van Lint… - The Journal of cell …, 2007 - rupress.org
Matrix metalloproteinase (MMP)-2 and -9 are pivotal in remodeling many tissues. However,
their functions and candidate substrates for brain development are poorly characterized. …

Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood–CSF barrier contributes to lethality during systemic inflammatory diseases

…, E Dejonckheere, P Van Lint… - Journal of …, 2012 - Soc Neuroscience
Systemic inflammatory response syndrome (SIRS) is a highly mortal inflammatory disease,
associated with systemic inflammation and organ dysfunction. SIRS can have a sterile cause …

Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis

P Van Lint, B Wielockx, L Puimège, A Noël… - The Journal of …, 2005 - journals.aai.org
Acute fulminant liver failure is a serious worldwide health problem. Despite maximal supportive
intensive care treatment, the disease offers a poor prognosis, with mortality rates of> 80%…

[HTML][HTML] Nationwide harmonization effort for semi-quantitative reporting of SARS-CoV-2 PCR test results in Belgium

…, P Van Lint, B Van den Poel, Y Van der Beken… - Viruses, 2022 - mdpi.com
From early 2020, a high demand for SARS-CoV-2 tests was driven by several testing
indications, including asymptomatic cases, resulting in the massive roll-out of PCR assays to …

Protection of zinc against tumor necrosis factor–induced lethal inflammation depends on heat shock protein 70 and allows safe antitumor therapy

…, M Van Roy, T Van Bogaert, L Dejager, P Van Lint… - Cancer research, 2007 - AACR
Tumor necrosis factor (TNF)–induced inflammation prevents its broad application as an
antitumor agent. We here report that addition of ZnSO 4 to the drinking water of mice induces …

Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNγ–based cancer therapy in mice

M Van Roy, P Van Lint, I Van Laere, B Wielockx… - Molecular Cancer …, 2007 - AACR
The potent antitumor activity of tumor necrosis factor (TNF) in combination with IFN-γ can
only be applied in local regimens due to their strong proinflammatory properties. It has been …

Value of pneumococcal PCR in respiratory samples for exclusion of pneumococcal pneumonia

S Van Goethem, P Van Lint, P Willems… - JAC-Antimicrobial …, 2023 - academic.oup.com
Background Streptococcus pneumoniae is the main aetiological agent in bacterial pneumonia.
Therefore pneumococcal PCR is often included in respiratory multiplex PCR panels, both …

Follow the Footprints to the Diagnosis in a Patient with Meningismus

…, R Madou, S Weekx, P Van Lint… - Clinical infectious …, 2010 - academic.oup.com
May-Grünwald-Giemsa staining of a cerebrospinal fluid specimen obtained from the patient
showed so-called footprint, or Mollaret, cells. These are large monocytes of atypical …