The roles of opioid receptors in pain and addiction have been extensively studied, but their
function in mood disorders has received less attention. Accumulating evidence from animal …

Comorbidity is a major issue in psychiatry that notably associates with more severe symptoms,
longer illness duration, and higher service utilization. Therefore, identifying key clusters of …

Childhood brain tumors have suspected prenatal origins. To identify vulnerable developmental
states, we generated a single-cell transcriptome atlas of >65,000 cells from embryonal …

Objective: Child abuse has devastating and long-lasting consequences, considerably
increasing the lifetime risk of negative mental health outcomes such as depression and suicide. …

Pain associates both sensory and emotional aversive components, and often leads to anxiety
and depression when it becomes chronic. Here, we characterized, in a mouse model, the …

BACKGROUND:: Opiate abuse is a chronic relapsing disorder, and maintaining prolonged
abstinence remains a major challenge. Protracted abstinence is characterized by lowered …

While depression and chronic pain are frequently comorbid, underlying neuronal circuits
and their psychopathological relevance remain poorly defined. Here we show in mice that …

Addiction is characterized by altered reward processing, disrupted emotional responses and
poor decision-making. Beyond a central role in drug reward, increasing evidence indicate …

Early life adversity remains a significant risk factor for the development of a host of negative
behavioural and pathological outcomes in adulthood long after the stressor is over. Recent …

In addition to treating depression, antidepressant drugs are also a first-line treatment for
neuropathic pain, which is pain secondary to lesion or pathology of the nervous system. Despite …