The role of the amygdala in the extinction of conditioned fear

M Barad, PW Gean, B Lutz - Biological psychiatry, 2006 - Elsevier
… Nevertheless, Po-Wu Gean and his colleagues have accumulated … Gean and his colleagues
demonstrated LTP and … In later experiments, the Gean group used a more typical behavioral …

[HTML][HTML] Impact of social relationships on Alzheimer's memory impairment: mechanistic studies

YH Hsiao, CH Chang, PW Gean - Journal of biomedical science, 2018 - Springer
gene expression, long-term synaptic plasticity, and memory retention [88,89,90,91]. … BDNF
gene expression in the hippocampus of rodents [92,93,94,95,96,97]. The mouse BDNF gene

Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes

…, X Wu, CC Wang, B Wilson, RB Lu, PW Gean… - Molecular …, 2006 - nature.com
Valproate (VPA), one of the mood stabilizers and antiepileptic drugs, was recently found to
inhibit histone deacetylases (HDAC). Increasing reports demonstrate that VPA has …

[HTML][HTML] A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala

…, SH Yeh, CH Lin, KT Lu, TH Leu, WC Chang, PW Gean - Neuron, 2001 - cell.com
Western blot analysis of neuronal tissues taken from fear-conditioned rats showed a selective
activation of phosphatidylinositol 3-kinase (PI-3 kinase) in the amygdala. PI-3 kinase was …

The similarities and diversities of signal pathways leading to consolidation of conditioning and consolidation of extinction of fear memory

CH Lin, SH Yeh, HY Lu, PW Gean - Journal of Neuroscience, 2003 - Soc Neuroscience
It is generally believed that consolidation of long-term memory requires activation of protein
kinases, transcription of genes, and new protein synthesis. However, little is known about the …

Acetylation of nuclear factor-κB in rat amygdala improves long-term but not short-term retention of fear memory

SH Yeh, CH Lin, PW Gean - Molecular pharmacology, 2004 - ASPET
Memory consolidation is mediated by new protein synthesis. However, the transcriptional
pathways induced in neurons by behavioral training that activate gene responses have yet to …

Involvement of a calcineurin cascade in amygdala depotentiation and quenching of fear memory

CH Lin, CC Lee, PW Gean - Molecular pharmacology, 2003 - ASPET
If fear memory is expressed by a long-term potentiation (LTP) of synaptic transmission in the
amygdala, then reversal of LTP (depotentiation) in this area of the brain may provide an …

Identification of calcineurin as a key signal in the extinction of fear memory

…, TH Leu, WC Chang, ST Wang, PW Gean - Journal of …, 2003 - Soc Neuroscience
Memory extinction refers to a gradual decrease of the previously acquired response when
exposed to conditional stimulus without pairing with unconditional stimulus. Here we show for …

Social interaction rescues memory deficit in an animal model of Alzheimer's disease by increasing BDNF-dependent hippocampal neurogenesis

…, HC Hung, SH Chen, PW Gean - Journal of …, 2014 - Soc Neuroscience
It has been recognized that the risk of cognitive decline during aging can be reduced if one
maintains strong social connections, yet the neural events underlying this beneficial effect …

The role of prefrontal cortex CB1 receptors in the modulation of fear memory

HC Lin, SC Mao, CL Su, PW Gean - Cerebral Cortex, 2009 - academic.oup.com
Understanding the mechanism of how fear memory can be extinguished could provide potential
therapeutic strategies for the treatment of posttraumatic stress disorders. Here we show …