Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of ITwindow

…, VN Uebele, V Crunelli, RC Lambert… - Journal of …, 2010 - Soc Neuroscience
Although it is well established that low-voltage-activated T-type Ca 2+ channels play a key
role in many neurophysiological functions and pathological states, the lack of selective and …

Essential thalamic contribution to slow waves of natural sleep

…, VN Uebele, JJ Renger, RC Lambert… - Journal of …, 2013 - Soc Neuroscience
Slow waves represent one of the prominent EEG signatures of non-rapid eye movement (non-REM)
sleep and are thought to play an important role in the cellular and network plasticity …

Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures

V Crunelli, ML Lőrincz, C McCafferty, RC Lambert… - Brain, 2020 - academic.oup.com
Absence seizures in children and teenagers are generally considered relatively benign
because of their non-convulsive nature and the large incidence of remittance in early adulthood. …

Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity

…, F David, SW Hughes, RC Lambert… - Nature Reviews …, 2018 - nature.com
During inattentive wakefulness and non-rapid eye movement (NREM) sleep, the neocortex
and thalamus cooperatively engage in rhythmic activities that are exquisitely reflected in the …

[HTML][HTML] From sleep spindles of natural sleep to spike and wave discharges of typical absence seizures: is the hypothesis still valid?

N Leresche, RC Lambert, AC Errington… - Pflügers Archiv-European …, 2012 - Springer
The temporal coincidence of sleep spindles and spike-and-wave discharges (SWDs) in
patients with idiopathic generalized epilepsies, together with the transformation of spindles into …

Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures

…, Z Atherton, G Recchia, G Orban, RC Lambert… - Nature …, 2018 - nature.com
Behaviorally and pathologically relevant cortico-thalamo-cortical oscillations are driven by
diverse interacting cell-intrinsic and synaptic processes. However, the mechanism that gives …

T-type calcium channels consolidate tonic action potential output of thalamic neurons to neocortex

…, VN Uebele, JJ Renger, RC Lambert… - Journal of …, 2012 - Soc Neuroscience
The thalamic output during different behavioral states is strictly controlled by the firing modes
of thalamocortical neurons. During sleep, their hyperpolarized membrane potential allows …

[PDF][PDF] Layer 2/3 pyramidal neurons control the gain of cortical output

…, SL Fayad, K Boutourlinsky, N Leresche, RC Lambert… - Cell reports, 2018 - cell.com
Initial anatomical and physiological studies suggested that sensory information relayed from
the periphery by the thalamus is serially processed in primary sensory cortical areas. It is …

Distinct kinetics of cloned T‐type Ca2 +  channels lead to differential Ca2 +  entry and frequency‐dependence during mock action potentials

…, E Perez‐Reyes, A Feltz, RC Lambert - European Journal of …, 1999 - Wiley Online Library
Voltage‐dependent activity around the resting potential is determinant in neuronal physiology
and participates in the definition of the firing pattern. Low‐voltage‐activated T‐type Ca 2 + …

The many faces of T-type calcium channels

RC Lambert, T Bessaďh, V Crunelli… - Pflügers Archiv-European …, 2014 - Springer
Since the discovery of low-voltage-activated T-type calcium channels in sensory neurons
and the initial characterization of their physiological function mainly in inferior olive and …