An inverse agonist of the histamine H3 receptor improves wakefulness in narcolepsy: studies in orexin−/− mice and patients
…, I Arnulf, H Bastuji, C Anaclet, R Parmentier… - Neurobiology of …, 2008 - Elsevier
Narcolepsy is characterized by excessive daytime sleepiness (EDS), cataplexy, direct onsets
of rapid eye movement (REM) sleep from wakefulness (DREMs) and deficiency of orexins, …
of rapid eye movement (REM) sleep from wakefulness (DREMs) and deficiency of orexins, …
Orexin/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models
C Anaclet, R Parmentier, K Ouk, G Guidon… - Journal of …, 2009 - Soc Neuroscience
To determine the respective role played by orexin/hypocretin and histamine (HA) neurons in
maintaining wakefulness (W), we characterized the behavioral and sleep–wake phenotypes …
maintaining wakefulness (W), we characterized the behavioral and sleep–wake phenotypes …
Anatomical, physiological, and pharmacological characteristics of histidine decarboxylase knock-out mice: evidence for the role of brain histamine in behavioral and …
R Parmentier, H Ohtsu, Z Djebbara-Hannas… - Journal of …, 2002 - Soc Neuroscience
The hypothesis that histaminergic neurons are involved in brain arousal is supported by many
studies. However, the effects of the selective long-term abolition of histaminergic neurons …
studies. However, the effects of the selective long-term abolition of histaminergic neurons …
Protean agonism at histamine H3 receptors in vitro and in vivo
…, A Rouleau, S Morisset, R Parmentier… - Proceedings of the …, 2003 - National Acad Sciences
G protein-coupled receptors (GPCRs) are allosteric proteins that adopt inactive (R) and active
(R * ) conformations in equilibrium. R * is promoted by agonists or occurs spontaneously, …
(R * ) conformations in equilibrium. R * is promoted by agonists or occurs spontaneously, …
Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2. 649
…, M Uguen, E Denis, P Robert, R Parmentier… - Biochemical …, 2007 - Elsevier
BF2.649, a high affinity and selective non-imidazole histamine H 3 -receptor antagonist/inverse
agonist, was found to easily enter the brain after oral administration to mice: it displayed …
agonist, was found to easily enter the brain after oral administration to mice: it displayed …
Electrophysiological evidence that the retrosplenial cortex displays a strong and specific activation phased with hippocampal theta during paradoxical (REM) sleep
…, A Tiran-Cappello, R Parmentier… - Journal of …, 2017 - Soc Neuroscience
It is widely accepted that cortical neurons are similarly more activated during waking and
paradoxical sleep (PS; aka REM) than during slow-wave sleep (SWS). However, we recently …
paradoxical sleep (PS; aka REM) than during slow-wave sleep (SWS). However, we recently …
The brain H3-receptor as a novel therapeutic target for vigilance and sleep–wake disorders
R Parmentier, C Anaclet, C Guhennec… - Biochemical …, 2007 - Elsevier
Brain histaminergic neurons play a prominent role in arousal and maintenance of wakefulness
(W). H 3 -receptors control the activity of histaminergic neurons through presynaptic …
(W). H 3 -receptors control the activity of histaminergic neurons through presynaptic …
Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: a study using a knockout mouse model
R Parmentier, Y Zhao, M Perier, H Akaoka… - …, 2016 - Elsevier
Using knockout (KO) mice lacking the histamine (HA)-synthesizing enzyme (histidine
decarboxylase, HDC), we have previously shown the importance of histaminergic neurons in …
decarboxylase, HDC), we have previously shown the importance of histaminergic neurons in …
Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone
R Parmentier, S Kolbaev, BP Klyuch… - Journal of …, 2009 - Soc Neuroscience
The histaminergic tuberomamillary nucleus (TMN) controls arousal and attention, and the
firing of TMN neurons is state-dependent, active during waking, silent during sleep. Thyrotropin…
firing of TMN neurons is state-dependent, active during waking, silent during sleep. Thyrotropin…
Differential changes in hippocampal CaMKII and GluA1 activity after memory training involving different levels of adaptive forgetting
…, MA Joseph, M Touret, R Parmentier… - Learning & …, 2017 - learnmem.cshlp.org
Phosphorylation of CaMKII and AMPA receptor GluA1 subunit has been shown to play a major
role in hippocampal-dependent long-term/reference memory (RM) and in the expression …
role in hippocampal-dependent long-term/reference memory (RM) and in the expression …