User profiles for Rachel Wragg

Rachel Wragg

Weill Cornell Medical College
Verified email at med.cornell.edu
Cited by 799

Tyramine and octopamine independently inhibit serotonin-stimulated aversive behaviors in Caenorhabditis elegans through two novel amine receptors

RT Wragg, V Hapiak, SB Miller, GP Harris… - Journal of …, 2007 - Soc Neuroscience
Biogenic amines modulate key behaviors in both vertebrates and invertebrates. In Caenorhabditis
elegans, tyramine (TA) and octopamine (OA) inhibit aversive responses to 100%, but …

Monoamines and neuropeptides interact to inhibit aversive behaviour in Caenorhabditis elegans

H Mills, R Wragg, V Hapiak, M Castelletto… - The EMBO …, 2012 - embopress.org
Pain modulation is complex, but noradrenergic signalling promotes anti‐nociception, with α
2 ‐adrenergic agonists used clinically. To better understand the noradrenergic/peptidergic …

Three distinct amine receptors operating at different levels within the locomotory circuit are each essential for the serotonergic modulation of chemosensation in …

GP Harris, VM Hapiak, RT Wragg, SB Miller… - Journal of …, 2009 - Soc Neuroscience
Serotonin modulates behavioral plasticity in both vertebrates and invertebrates and in
Caenorhabditis elegans regulates key behaviors, including locomotion, aversive learning and …

The monoaminergic modulation of sensory-mediated aversive responses in Caenorhabditis elegans requires glutamatergic/peptidergic cotransmission

G Harris, H Mills, R Wragg, V Hapiak… - Journal of …, 2010 - Soc Neuroscience
Monoamines and neuropeptides interact to modulate behavioral plasticity in both vertebrates
and invertebrates. In Caenorhabditis elegans behavioral state or “mood” is dependent on …

[PDF][PDF] Synaptic vesicles position complexin to block spontaneous fusion

RT Wragg, D Snead, Y Dong, TF Ramlall, I Menon… - Neuron, 2013 - cell.com
Synapses continually replenish their synaptic vesicle (SV) pools while suppressing
spontaneous fusion events, thus maintaining a high dynamic range in response to physiological …

[HTML][HTML] Membrane curvature sensing by the C-terminal domain of complexin

D Snead, RT Wragg, JS Dittman, D Eliezer - Nature communications, 2014 - nature.com
Complexin functions at presynaptic nerve terminals to inhibit spontaneous SNARE-mediated
synaptic vesicle (SV) exocytosis, while enhancing stimulated neurotransmitter release. The …

[HTML][HTML] Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones

…, D Abramov, P Kharel, KE Carnazza, RT Wragg… - Nature …, 2018 - nature.com
Heterozygous de novo mutations in the neuronal protein Munc18-1 are linked to epilepsies,
intellectual disability, movement disorders, and neurodegeneration. These devastating …

[HTML][HTML] Unique structural features of membrane-bound C-terminal domain motifs modulate complexin inhibitory function

D Snead, AL Lai, RT Wragg, DA Parisotto… - Frontiers in molecular …, 2017 - frontiersin.org
Complexin is a small soluble presynaptic protein that interacts with neuronal SNARE proteins
in order to regulate synaptic vesicle exocytosis. While the SNARE-binding central helix of …

[HTML][HTML] Evolutionary divergence of the c-terminal domain of complexin accounts for functional disparities between vertebrate and invertebrate complexins

RT Wragg, DA Parisotto, Z Li, MS Terakawa… - Frontiers in molecular …, 2017 - frontiersin.org
Complexin is a critical presynaptic protein that regulates both spontaneous and calcium-triggered
neurotransmitter release in all synapses. Although the SNARE-binding central helix of …

Monoamines activate neuropeptide signaling cascades to modulate nociception in C. elegans: a useful model for the modulation of chronic pain?

R Komuniecki, G Harris, V Hapiak, R Wragg… - Invertebrate …, 2012 - Springer
Monoamines and neuropeptides interact to modulate key behaviors in most organisms. This
review is focused on the interaction between octopamine (OA) and an array of …