User profiles for Rachel Wragg
Rachel WraggWeill Cornell Medical College Verified email at med.cornell.edu Cited by 799 |
Tyramine and octopamine independently inhibit serotonin-stimulated aversive behaviors in Caenorhabditis elegans through two novel amine receptors
RT Wragg, V Hapiak, SB Miller, GP Harris… - Journal of …, 2007 - Soc Neuroscience
Biogenic amines modulate key behaviors in both vertebrates and invertebrates. In Caenorhabditis
elegans, tyramine (TA) and octopamine (OA) inhibit aversive responses to 100%, but …
elegans, tyramine (TA) and octopamine (OA) inhibit aversive responses to 100%, but …
Monoamines and neuropeptides interact to inhibit aversive behaviour in Caenorhabditis elegans
H Mills, R Wragg, V Hapiak, M Castelletto… - The EMBO …, 2012 - embopress.org
Pain modulation is complex, but noradrenergic signalling promotes anti‐nociception, with α
2 ‐adrenergic agonists used clinically. To better understand the noradrenergic/peptidergic …
2 ‐adrenergic agonists used clinically. To better understand the noradrenergic/peptidergic …
Three distinct amine receptors operating at different levels within the locomotory circuit are each essential for the serotonergic modulation of chemosensation in …
GP Harris, VM Hapiak, RT Wragg, SB Miller… - Journal of …, 2009 - Soc Neuroscience
Serotonin modulates behavioral plasticity in both vertebrates and invertebrates and in
Caenorhabditis elegans regulates key behaviors, including locomotion, aversive learning and …
Caenorhabditis elegans regulates key behaviors, including locomotion, aversive learning and …
The monoaminergic modulation of sensory-mediated aversive responses in Caenorhabditis elegans requires glutamatergic/peptidergic cotransmission
G Harris, H Mills, R Wragg, V Hapiak… - Journal of …, 2010 - Soc Neuroscience
Monoamines and neuropeptides interact to modulate behavioral plasticity in both vertebrates
and invertebrates. In Caenorhabditis elegans behavioral state or “mood” is dependent on …
and invertebrates. In Caenorhabditis elegans behavioral state or “mood” is dependent on …
[PDF][PDF] Synaptic vesicles position complexin to block spontaneous fusion
Synapses continually replenish their synaptic vesicle (SV) pools while suppressing
spontaneous fusion events, thus maintaining a high dynamic range in response to physiological …
spontaneous fusion events, thus maintaining a high dynamic range in response to physiological …
[HTML][HTML] Membrane curvature sensing by the C-terminal domain of complexin
Complexin functions at presynaptic nerve terminals to inhibit spontaneous SNARE-mediated
synaptic vesicle (SV) exocytosis, while enhancing stimulated neurotransmitter release. The …
synaptic vesicle (SV) exocytosis, while enhancing stimulated neurotransmitter release. The …
[HTML][HTML] Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones
Heterozygous de novo mutations in the neuronal protein Munc18-1 are linked to epilepsies,
intellectual disability, movement disorders, and neurodegeneration. These devastating …
intellectual disability, movement disorders, and neurodegeneration. These devastating …
[HTML][HTML] Unique structural features of membrane-bound C-terminal domain motifs modulate complexin inhibitory function
Complexin is a small soluble presynaptic protein that interacts with neuronal SNARE proteins
in order to regulate synaptic vesicle exocytosis. While the SNARE-binding central helix of …
in order to regulate synaptic vesicle exocytosis. While the SNARE-binding central helix of …
[HTML][HTML] Evolutionary divergence of the c-terminal domain of complexin accounts for functional disparities between vertebrate and invertebrate complexins
RT Wragg, DA Parisotto, Z Li, MS Terakawa… - Frontiers in molecular …, 2017 - frontiersin.org
Complexin is a critical presynaptic protein that regulates both spontaneous and calcium-triggered
neurotransmitter release in all synapses. Although the SNARE-binding central helix of …
neurotransmitter release in all synapses. Although the SNARE-binding central helix of …
Monoamines activate neuropeptide signaling cascades to modulate nociception in C. elegans: a useful model for the modulation of chronic pain?
R Komuniecki, G Harris, V Hapiak, R Wragg… - Invertebrate …, 2012 - Springer
Monoamines and neuropeptides interact to modulate key behaviors in most organisms. This
review is focused on the interaction between octopamine (OA) and an array of …
review is focused on the interaction between octopamine (OA) and an array of …