Three glutamate transporters have been identified in rat, including astroglial transporters
GLAST and GLT-1 and a neuronal transporter EAAC1. Here we demonstrate that inhibition of …

The cellular and subcellular distributions of the glutamate transporter subtypes EAACl, CLT-1,
and CIAST in the rat CNS were demonstrated using anti-peptide antibodies that recognize …

The pathogenesis of sporadic amyotrophic lateral sclerosis (ALS) is unknown, but defects in
synaptosomal high‐affinity glutamate transport have been observed. In experimental models…

Background. Amyotrophic lateral sclerosis (ALS) is a chronic degenerative neurologic
disorder characterized by the death of motor neurons in the cerebral cortex and spinal cord. …

Recently, the excitatory amino acid neurotransmitter glutamate was implicated in the
pathogenesis of a variety of chronic degenerative neurological diseases in humans and animals. …

Defects in neurotransmitter glutamate transport may be an important component of chronic
neurotoxicity in diseases such as amyotrophic lateral sclerosis. There are no reliable models …

Although colchicine has been used for centuries, its neuromuscular toxicity in humans is
largely unrecognized. In this report we describe a characteristic syndrome of myopathy and …

Mutations in the gene for Cu/Zn superoxide dismutase (SOD1) have been detected in some
families with an autosomal dominant form of amyotrophic lateral sclerosis; these mutations …

Although pigment epithelium-derived factor (PEDF) is a neurotrophic factor that may aid the
development, differentiation, and survival of adjacent neural retinae, the wider distribution of …

A dramatic loss of glutamate transport has been observed in sporadic amyotrophic lateral
sclerosis and has been postulated to contribute to the disease. Experimentally, this hypothesis …