Ascending and descending information is relayed through the thalamus via strong, “driver”
pathways. According to our current knowledge, different driver pathways are organized in …

A major synaptic input to the thalamus originates from neurons in cortical layer 6 (L6);
however, the function of this cortico–thalamic pathway during sensory processing is not well …

In the mammalian brain, thalamic signals reach the cortex via two major routes: primary and
higher-order thalamocortical pathways. While primary thalamocortical nuclei transmit …

The transmission of noxious stimuli from peripheral receptors to the cortex involves multiple
central ascending pathways. While projections to areas in the brainstem and diencephalon …

High-frequency "burst" clusters of spikes are a generic output pattern of many neurons. While
bursting is a ubiquitous computational feature of different nervous systems across animal …

Diversity of cell-types that collectively shape the cortical microcircuit ensures the necessary
computational richness to orchestrate a wide variety of behaviors. The information content …

Large portions of the thalamus receive strong driving input from cortical layer 5 (L5) neurons
but the role of this important pathway in cortical and thalamic computations is not well …

Cortical layer 5B (L5B) thick-tufted pyramidal neurons have reliable responses to whisker
stimulation in anesthetized rodents. These cells drive a corticothalamic pathway that evokes …

Neurons in cortical layer 5B (L5B) connect the cortex to numerous subcortical areas. Possibly
the best-studied L5B cortico–subcortical connection is that between L5B neurons in the …

The cortex connects to the thalamus via extensive corticothalamic (CT) pathways, but their
function in vivo is not well understood. We investigated “top-down” signaling from cortex to …